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Water (M2MDB000142)
Enzymes
- General function:
- Involved in oxidoreductase activity
- Specific function:
- L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH
- Gene Name:
- gdhA
- Uniprot ID:
- P00370
- Molecular weight:
- 48581
Reactions
| L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH. |
- General function:
- Involved in oxidation-reduction process
- Specific function:
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines
- Gene Name:
- nrdA
- Uniprot ID:
- P00452
- Molecular weight:
- 85774
Reactions
| 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. |
- General function:
- Involved in catalytic activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- phoA
- Uniprot ID:
- P00634
- Molecular weight:
- 49438
Reactions
| A phosphate monoester + H(2)O = an alcohol + phosphate. |
- General function:
- Involved in beta-galactosidase activity
- Specific function:
- Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides
- Gene Name:
- lacZ
- Uniprot ID:
- P00722
- Molecular weight:
- 116482
Reactions
| Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. |
- General function:
- Involved in asparaginase activity
- Specific function:
- L-asparagine + H(2)O = L-aspartate + NH(3)
- Gene Name:
- ansB
- Uniprot ID:
- P00805
- Molecular weight:
- 36851
Reactions
| L-asparagine + H(2)O = L-aspartate + NH(3). |
- General function:
- Involved in beta-lactamase activity
- Specific function:
- This protein is a serine beta-lactamase with a substrate specificity for cephalosporins
- Gene Name:
- ampC
- Uniprot ID:
- P00811
- Molecular weight:
- 41555
Reactions
| A beta-lactam + H(2)O = a substituted beta-amino acid. |
- General function:
- Involved in phosphoenolpyruvate carboxylase activity
- Specific function:
- Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
- Gene Name:
- ppc
- Uniprot ID:
- P00864
- Molecular weight:
- 99062
Reactions
| Phosphate + oxaloacetate = H(2)O + phosphoenolpyruvate + HCO(3)(-). |
- General function:
- Involved in catalytic activity
- Specific function:
- Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
- Gene Name:
- aroH
- Uniprot ID:
- P00887
- Molecular weight:
- 38735
Reactions
| Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
- Gene Name:
- aroF
- Uniprot ID:
- P00888
- Molecular weight:
- 38804
Reactions
| Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. |
- General function:
- Involved in biosynthetic process
- Specific function:
- Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
- Gene Name:
- trpE
- Uniprot ID:
- P00895
- Molecular weight:
- 57494
Reactions
| Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. |
- General function:
- Involved in anthranilate phosphoribosyltransferase activity
- Specific function:
- Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
- Gene Name:
- trpD
- Uniprot ID:
- P00904
- Molecular weight:
- 56869
Reactions
| Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. |
| N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain
- Gene Name:
- trpC
- Uniprot ID:
- P00909
- Molecular weight:
- 49361
Reactions
| N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. |
| 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O. |
- General function:
- Involved in D-serine ammonia-lyase activity
- Specific function:
- D-serine = pyruvate + NH(3)
- Gene Name:
- dsdA
- Uniprot ID:
- P00926
- Molecular weight:
- 47900
Reactions
| D-serine = pyruvate + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction
- Gene Name:
- thrC
- Uniprot ID:
- P00934
- Molecular weight:
- 47113
Reactions
| O-phospho-L-homoserine + H(2)O = L-threonine + phosphate. |
- General function:
- Involved in pyridoxal phosphate binding
- Specific function:
- O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate
- Gene Name:
- metB
- Uniprot ID:
- P00935
- Molecular weight:
- 41550
Reactions
| O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate. |
- General function:
- Involved in ATP binding
- Specific function:
- 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
- Gene Name:
- carB
- Uniprot ID:
- P00968
- Molecular weight:
- 117841
Reactions
| 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
- General function:
- Involved in potassium-transporting ATPase activity
- Specific function:
- One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
- Gene Name:
- kdpA
- Uniprot ID:
- P03959
- Molecular weight:
- 59189
Reactions
| ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
- Gene Name:
- kdpB
- Uniprot ID:
- P03960
- Molecular weight:
- 72198
Reactions
| ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In). |
- General function:
- Involved in potassium-transporting ATPase activity
- Specific function:
- One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
- Gene Name:
- kdpC
- Uniprot ID:
- P03961
- Molecular weight:
- 20267
Reactions
| ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In). |
- General function:
- Involved in dihydrodipicolinate reductase activity
- Specific function:
- 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H
- Gene Name:
- dapB
- Uniprot ID:
- P04036
- Molecular weight:
- 28756
Reactions
| (S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = (S)-2,3-dihydrodipicolinate + NAD(P)H. |
- General function:
- Involved in GMP synthase (glutamine-hydrolyzing) activity
- Specific function:
- Catalyzes the synthesis of GMP from XMP
- Gene Name:
- guaA
- Uniprot ID:
- P04079
- Molecular weight:
- 58679
Reactions
| ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate. |
- General function:
- Involved in proteolysis
- Specific function:
- Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation
- Gene Name:
- pepN
- Uniprot ID:
- P04825
- Molecular weight:
- 98918
Reactions
| Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent
- Gene Name:
- ilvA
- Uniprot ID:
- P04968
- Molecular weight:
- 56195
Reactions
| L-threonine = 2-oxobutanoate + NH(3). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system
- Gene Name:
- rbsA
- Uniprot ID:
- P04983
- Molecular weight:
- 55041
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in hydrolase activity
- Specific function:
- (S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate
- Gene Name:
- pyrC
- Uniprot ID:
- P05020
- Molecular weight:
- 38827
Reactions
| (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate. |
- General function:
- Involved in biosynthetic process
- Specific function:
- Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine
- Gene Name:
- pabB
- Uniprot ID:
- P05041
- Molecular weight:
- 50969
Reactions
| Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate. |
- General function:
- Involved in fumarate hydratase activity
- Specific function:
- (S)-malate = fumarate + H(2)O
- Gene Name:
- fumC
- Uniprot ID:
- P05042
- Molecular weight:
- 50488
Reactions
| (S)-malate = fumarate + H(2)O. |
- General function:
- Involved in 3-dehydroquinate dehydratase activity
- Specific function:
- 3-dehydroquinate = 3-dehydroshikimate + H(2)O
- Gene Name:
- aroD
- Uniprot ID:
- P05194
- Molecular weight:
- 27466
Reactions
| 3-dehydroquinate = 3-dehydroshikimate + H(2)O. |
- General function:
- Involved in catalytic activity
- Specific function:
- Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin
- Gene Name:
- ptrA
- Uniprot ID:
- P05458
- Molecular weight:
- 107708
Reactions
| Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon. |
- General function:
- Involved in bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
- Specific function:
- Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
- Gene Name:
- apaH
- Uniprot ID:
- P05637
- Molecular weight:
- 31296
Reactions
| P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP. |
- General function:
- Involved in metabolic process
- Specific function:
- 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2- oxobutanoate + H(2)O
- Gene Name:
- ilvD
- Uniprot ID:
- P05791
- Molecular weight:
- 65531
Reactions
| 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H(2)O. |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol
- Gene Name:
- uidA
- Uniprot ID:
- P05804
- Molecular weight:
- 68447
Reactions
| A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol. |
- General function:
- Involved in lyase activity
- Specific function:
- (R,R)-tartrate = oxaloacetate + H(2)O
- Gene Name:
- ttdA
- Uniprot ID:
- P05847
- Molecular weight:
- 32733
Reactions
| (R,R)-tartrate = oxaloacetate + H(2)O. |
- General function:
- Involved in CDP-diacylglycerol diphosphatase activity
- Specific function:
- CDP-diacylglycerol + H(2)O = CMP + phosphatidate
- Gene Name:
- cdh
- Uniprot ID:
- P06282
- Molecular weight:
- 28451
Reactions
| CDP-diacylglycerol + H(2)O = CMP + phosphatidate. |
- General function:
- Involved in glutathione peroxidase activity
- Specific function:
- Not essential for B12 transport; however, it is an auxiliary component of the transport system
- Gene Name:
- btuE
- Uniprot ID:
- P06610
- Molecular weight:
- 20469
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
- Gene Name:
- btuD
- Uniprot ID:
- P06611
- Molecular weight:
- 27081
Reactions
| ATP + H(2)O + vitamin B12(Out) = ADP + phosphate + vitamin B12(In). |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Hydrolysis of terminal, non-reducing alpha-D- galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids
- Gene Name:
- melA
- Uniprot ID:
- P06720
- Molecular weight:
- 50657
Reactions
| Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. |
- General function:
- Involved in pyridoxal phosphate binding
- Specific function:
- L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate
- Gene Name:
- metC
- Uniprot ID:
- P06721
- Molecular weight:
- 43212
Reactions
| L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate. |
- General function:
- Involved in beta-galactosidase activity
- Specific function:
- The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme
- Gene Name:
- ebgA
- Uniprot ID:
- P06864
- Molecular weight:
- 117878
Reactions
| Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. |
- General function:
- Involved in hydrolase activity
- Specific function:
- This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
- Gene Name:
- dut
- Uniprot ID:
- P06968
- Molecular weight:
- 16155
Reactions
| dUTP + H(2)O = dUMP + diphosphate. |
- General function:
- Involved in hydroxymethylbilane synthase activity
- Specific function:
- Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
- Gene Name:
- hemC
- Uniprot ID:
- P06983
- Molecular weight:
- 33851
Reactions
| 4 porphobilinogen + H(2)O = hydroxymethylbilane + 4 NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- D-erythro-1-(imidazol-4-yl)glycerol 3- phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O
- Gene Name:
- hisB
- Uniprot ID:
- P06987
- Molecular weight:
- 40278
Reactions
| D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O. |
| L-histidinol phosphate + H(2)O = L-histidinol + phosphate. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
- Gene Name:
- hisD
- Uniprot ID:
- P06988
- Molecular weight:
- 46110
Reactions
| L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH. |
- General function:
- Involved in phosphoribosyl-AMP cyclohydrolase activity
- Specific function:
- 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5- phosphoribosyl)-AMP + diphosphate
- Gene Name:
- hisI
- Uniprot ID:
- P06989
- Molecular weight:
- 22756
Reactions
| 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-AMP + diphosphate. |
| 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. |
- General function:
- Lipid transport and metabolism
- Specific function:
- 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
- Gene Name:
- pldB
- Uniprot ID:
- P07000
- Molecular weight:
- 38978
Reactions
| 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Pyruvate + ferricytochrome b1 + H(2)O = acetate + CO(2) + ferrocytochrome b1
- Gene Name:
- poxB
- Uniprot ID:
- P07003
- Molecular weight:
- 62011
Reactions
| Pyruvate + ubiquinone + H(2)O = acetate + CO(2) + ubiquinol. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell
- Gene Name:
- ushA
- Uniprot ID:
- P07024
- Molecular weight:
- 60824
Reactions
| UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate. |
| A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- appA
- Uniprot ID:
- P07102
- Molecular weight:
- 47056
Reactions
| A phosphate monoester + H(2)O = an alcohol + phosphate. |
| Myo-inositol hexakisphosphate + H(2)O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system
- Gene Name:
- hisP
- Uniprot ID:
- P07109
- Molecular weight:
- 28653
- General function:
- Involved in two-component response regulator activity
- Specific function:
- Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
- Gene Name:
- cheB
- Uniprot ID:
- P07330
- Molecular weight:
- 37467
Reactions
| Protein L-glutamate O(5)-methyl ester + H(2)O = protein L-glutamate + methanol. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system
- Gene Name:
- fhuC
- Uniprot ID:
- P07821
- Molecular weight:
- 28886
Reactions
| ATP + H(2)O + iron chelate(Out) = ADP + phosphate + iron chelate(In). |
- General function:
- Involved in hydroxymethyl-, formyl- and related transferase activity
- Specific function:
- 10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide
- Gene Name:
- purN
- Uniprot ID:
- P08179
- Molecular weight:
- 23238
Reactions
| 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide. |
- General function:
- Involved in oxidation-reduction process
- Specific function:
- Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H
- Gene Name:
- nirB
- Uniprot ID:
- P08201
- Molecular weight:
- 93121
Reactions
| Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H. |
- General function:
- Involved in hydrolase activity
- Specific function:
- This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate
- Gene Name:
- cpdB
- Uniprot ID:
- P08331
- Molecular weight:
- 70832
Reactions
| Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 3'-phosphate. |
| A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA
- Gene Name:
- aceB
- Uniprot ID:
- P08997
- Molecular weight:
- 60273
Reactions
| Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA. |
- General function:
- Involved in uroporphyrinogen-III synthase activity
- Specific function:
- Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III
- Gene Name:
- hemD
- Uniprot ID:
- P09126
- Molecular weight:
- 27798
Reactions
| Hydroxymethylbilane = uroporphyrinogen III + H(2)O. |
- General function:
- Involved in 2-isopropylmalate synthase activity
- Specific function:
- Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
- Gene Name:
- leuA
- Uniprot ID:
- P09151
- Molecular weight:
- 57297
Reactions
| Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The alpha chain is the actual site of nitrate reduction
- Gene Name:
- narG
- Uniprot ID:
- P09152
- Molecular weight:
- 140489
Reactions
| Nitrite + acceptor = nitrate + reduced acceptor. |
- General function:
- Involved in glycerophosphodiester phosphodiesterase activity
- Specific function:
- Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols
- Gene Name:
- glpQ
- Uniprot ID:
- P09394
- Molecular weight:
- 40843
Reactions
| A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon
- Gene Name:
- putA
- Uniprot ID:
- P09546
- Molecular weight:
- 143814
Reactions
| L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. |
| (S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H. |
- General function:
- Involved in catalytic activity
- Specific function:
- 2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH
- Gene Name:
- gltB
- Uniprot ID:
- P09831
- Molecular weight:
- 166708
Reactions
| 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH. |
- General function:
- Involved in iron-sulfur cluster binding
- Specific function:
- 2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH
- Gene Name:
- gltD
- Uniprot ID:
- P09832
- Molecular weight:
- 52015
Reactions
| 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH. |
- General function:
- Involved in 3-isopropylmalate dehydratase activity
- Specific function:
- Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
- Gene Name:
- leuC
- Uniprot ID:
- P0A6A6
- Molecular weight:
- 49882
Reactions
| (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmaleate + H(2)O. |
| (2S)-2-isopropylmaleate + H(2)O = (2S)-2-isopropylmalate. |
- General function:
- Involved in metabolic process
- Specific function:
- Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate
- Gene Name:
- iscS
- Uniprot ID:
- P0A6B7
- Molecular weight:
- 45089
Reactions
| L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor. |
- General function:
- Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism
- Specific function:
- Produces ATP from ADP in the presence of a proton gradient across the membrane
- Gene Name:
- atpC
- Uniprot ID:
- P0A6E6
- Molecular weight:
- 15068
- General function:
- Involved in glutamine catabolic process
- Specific function:
- 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
- Gene Name:
- carA
- Uniprot ID:
- P0A6F1
- Molecular weight:
- 41431
Reactions
| 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
- General function:
- Involved in D-amino-acid dehydrogenase activity
- Specific function:
- Oxidative deamination of D-amino acids
- Gene Name:
- dadA
- Uniprot ID:
- P0A6J5
- Molecular weight:
- 47607
Reactions
| A D-amino acid + H(2)O + acceptor = a 2-oxo acid + NH(3) + reduced acceptor. |
- General function:
- Involved in iron ion binding
- Specific function:
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
- Gene Name:
- def
- Uniprot ID:
- P0A6K3
- Molecular weight:
- 19328
Reactions
| Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide. |
- General function:
- Involved in catalytic activity
- Specific function:
- L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O
- Gene Name:
- dapA
- Uniprot ID:
- P0A6L2
- Molecular weight:
- 31270
Reactions
| L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. It is also a component of the RNA degradosome, a multi-enzyme complex involved in RNA processing and messenger RNA degradation. Its interaction with RNase E is important for the turnover of mRNA, in particular on transcripts encoding enzymes of energy-generating metabolic routes. Its presence in the degradosome is required for the response to excess phosphosugar. May play a regulatory role in the degradation of specific RNAs, such as ptsG mRNA, therefore linking cellular metabolic status with post-translational gene regulation
- Gene Name:
- eno
- Uniprot ID:
- P0A6P9
- Molecular weight:
- 45655
Reactions
| 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O. |
- General function:
- Involved in catalytic activity
- Specific function:
- Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP
- Gene Name:
- fabA
- Uniprot ID:
- P0A6Q3
- Molecular weight:
- 18969
Reactions
| (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H(2)O. |
| (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein] + H(2)O. |
- General function:
- Involved in GTP cyclohydrolase I activity
- Specific function:
- GTP + H(2)O = formate + 2-amino-4-hydroxy-6- (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
- Gene Name:
- folE
- Uniprot ID:
- P0A6T5
- Molecular weight:
- 24830
Reactions
| GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. |
- General function:
- Involved in glutaminase activity
- Specific function:
- L-glutamine + H(2)O = L-glutamate + NH(3)
- Gene Name:
- glsA2
- Uniprot ID:
- P0A6W0
- Molecular weight:
- 33515
Reactions
| L-glutamine + H(2)O = L-glutamate + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth
- Gene Name:
- kdsA
- Uniprot ID:
- P0A715
- Molecular weight:
- 30833
Reactions
| Phosphoenolpyruvate + D-arabinose 5-phosphate + H(2)O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. |
- General function:
- Involved in UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
- Specific function:
- The key enzyme in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Degraded by FtsH; when the activity of FtsH is reduced too much lipid A and not enough phospholipids are made (both pathways use the same precursor), which is lethal
- Gene Name:
- lpxC
- Uniprot ID:
- P0A725
- Molecular weight:
- 33956
Reactions
| UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H(2)O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. |
- General function:
- Involved in oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
- Specific function:
- Could have an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
- Gene Name:
- msrA
- Uniprot ID:
- P0A744
- Molecular weight:
- 23315
Reactions
| Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. |
| L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin. |
- General function:
- Involved in peptide-methionine-(S)-S-oxide reductase activity
- Specific function:
- Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin
- Gene Name:
- msrB
- Uniprot ID:
- P0A746
- Molecular weight:
- 15451
Reactions
| Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin. |
- General function:
- Involved in carbohydrate metabolic process
- Specific function:
- Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
- Gene Name:
- nagB
- Uniprot ID:
- P0A759
- Molecular weight:
- 29774
Reactions
| D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3). |
- General function:
- Involved in hydrolase activity
- Specific function:
- Master regulator of 5'-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa- and tetra-phosphate. Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP- glucose. In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro
- Gene Name:
- rppH
- Uniprot ID:
- P0A776
- Molecular weight:
- 20795
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
- Gene Name:
- pdxJ
- Uniprot ID:
- P0A794
- Molecular weight:
- 26384
Reactions
| 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H(2)O. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Diphosphate + H(2)O = 2 phosphate
- Gene Name:
- ppa
- Uniprot ID:
- P0A7A9
- Molecular weight:
- 19703
Reactions
| Diphosphate + H(2)O = 2 phosphate. |
- General function:
- Involved in aminoacyl-tRNA hydrolase activity
- Specific function:
- The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death
- Gene Name:
- pth
- Uniprot ID:
- P0A7D1
- Molecular weight:
- 21082
Reactions
| N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA. |
- General function:
- Involved in CTP synthase activity
- Specific function:
- Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
- Gene Name:
- pyrG
- Uniprot ID:
- P0A7E5
- Molecular weight:
- 60374
Reactions
| ATP + UTP + NH(3) = ADP + phosphate + CTP. |
- General function:
- Involved in GTP cyclohydrolase II activity
- Specific function:
- Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
- Gene Name:
- ribA
- Uniprot ID:
- P0A7I7
- Molecular weight:
- 21836
Reactions
| GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate. |
- General function:
- Involved in ribonuclease H activity
- Specific function:
- Endonuclease that specifically degrades the RNA of RNA- DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer
- Gene Name:
- rnhA
- Uniprot ID:
- P0A7Y4
- Molecular weight:
- 17597
Reactions
| Endonucleolytic cleavage to 5'-phosphomonoester. |
- General function:
- Involved in methionine adenosyltransferase activity
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth
- Gene Name:
- metK
- Uniprot ID:
- P0A817
- Molecular weight:
- 41951
Reactions
| ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in catalytic activity
- Specific function:
- Interconversion of serine and glycine
- Gene Name:
- glyA
- Uniprot ID:
- P0A825
- Molecular weight:
- 45316
Reactions
| 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase
- Gene Name:
- surE
- Uniprot ID:
- P0A840
- Molecular weight:
- 26900
Reactions
| A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. |
| A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. |
| (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. |
- General function:
- Involved in lyase activity
- Specific function:
- L-tryptophan + H(2)O = indole + pyruvate + NH(3)
- Gene Name:
- tnaA
- Uniprot ID:
- P0A853
- Molecular weight:
- 52773
Reactions
| L-tryptophan + H(2)O = indole + pyruvate + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
- Gene Name:
- trpA
- Uniprot ID:
- P0A877
- Molecular weight:
- 28724
Reactions
| L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O. |
- General function:
- Involved in catalytic activity
- Specific function:
- The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
- Gene Name:
- trpB
- Uniprot ID:
- P0A879
- Molecular weight:
- 42983
Reactions
| L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O. |
- General function:
- Involved in phosphatidylserine decarboxylase activity
- Specific function:
- Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2)
- Gene Name:
- psd
- Uniprot ID:
- P0A8K1
- Molecular weight:
- 35934
Reactions
| Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2). |
- General function:
- Involved in catalytic activity
- Specific function:
- Nucleotidase that shows high phosphatase activity toward three nucleoside 5'-monophosphates, UMP, dUMP, and dTMP, and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Is strictly specific to substrates with 5'- phosphates and shows no activity against nucleoside 2'- or 3'- monophosphates. Might be involved in the pyrimidine nucleotide substrate cycles
- Gene Name:
- yjjG
- Uniprot ID:
- P0A8Y1
- Molecular weight:
- 25300
Reactions
| A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates erythrose 4-phosphate and mannose 1-phosphate
- Gene Name:
- yidA
- Uniprot ID:
- P0A8Y5
- Molecular weight:
- 29721
- General function:
- Involved in phospholipase activity
- Specific function:
- Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Strong expression leads to outer membrane breakdown and cell death; is dormant in normal growing cells. Required for efficient secretion of bacteriocins
- Gene Name:
- pldA
- Uniprot ID:
- P0A921
- Molecular weight:
- 33163
Reactions
| Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate. |
| Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Hydrolyzes phosphatidylglycerophosphate, phosphatidic acid, and lysophosphatidic acid; the pattern of activities varies according to subcellular location
- Gene Name:
- pgpB
- Uniprot ID:
- P0A924
- Molecular weight:
- 29021
Reactions
| Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. |
- General function:
- Involved in asparaginase activity
- Specific function:
- L-asparagine + H(2)O = L-aspartate + NH(3)
- Gene Name:
- ansA
- Uniprot ID:
- P0A962
- Molecular weight:
- 37127
Reactions
| L-asparagine + H(2)O = L-aspartate + NH(3). |
- General function:
- Involved in phosphoric ester hydrolase activity
- Specific function:
- D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate
- Gene Name:
- fbp
- Uniprot ID:
- P0A993
- Molecular weight:
- 36834
Reactions
| D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate. |
- General function:
- Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
- Specific function:
- D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
- Gene Name:
- gapA
- Uniprot ID:
- P0A9B2
- Molecular weight:
- 35532
Reactions
| D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH. |
- General function:
- Involved in erythrose-4-phosphate dehydrogenase activity
- Specific function:
- Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate
- Gene Name:
- epd
- Uniprot ID:
- P0A9B6
- Molecular weight:
- 37299
Reactions
| D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH. |
- General function:
- Involved in glycerol metabolic process
- Specific function:
- D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate
- Gene Name:
- glpX
- Uniprot ID:
- P0A9C9
- Molecular weight:
- 35852
Reactions
| D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate. |
- General function:
- Involved in protein binding
- Specific function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
- Gene Name:
- gst
- Uniprot ID:
- P0A9D2
- Molecular weight:
- 22868
Reactions
| RX + glutathione = HX + R-S-glutathione. |
- General function:
- Involved in 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
- Specific function:
- Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine- 2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6- oxoheptanedioate
- Gene Name:
- dapD
- Uniprot ID:
- P0A9D8
- Molecular weight:
- 29892
Reactions
| Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. |
- General function:
- Involved in nitrite reductase [NAD(P)H] activity
- Specific function:
- Required for activity of the reductase
- Gene Name:
- nirD
- Uniprot ID:
- P0A9I8
- Molecular weight:
- 12284
Reactions
| Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H. |
- General function:
- Involved in chorismate mutase activity
- Specific function:
- Chorismate = prephenate
- Gene Name:
- pheA
- Uniprot ID:
- P0A9J8
- Molecular weight:
- 43111
Reactions
| Chorismate = prephenate. |
| Prephenate = phenylpyruvate + H(2)O + CO(2). |
- General function:
- Involved in [formate-C-acetyltransferase]-activating enzyme activity
- Specific function:
- Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
- Gene Name:
- nrdG
- Uniprot ID:
- P0A9N8
- Molecular weight:
- 17446
- General function:
- Involved in oxidation-reduction process
- Specific function:
- Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
- Gene Name:
- trxB
- Uniprot ID:
- P0A9P4
- Molecular weight:
- 34623
Reactions
| Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH. |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity
- Gene Name:
- accD
- Uniprot ID:
- P0A9Q5
- Molecular weight:
- 33322
Reactions
| ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. |
- General function:
- Involved in protein tyrosine phosphatase activity
- Specific function:
- Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium
- Gene Name:
- wzb
- Uniprot ID:
- P0AAB2
- Molecular weight:
- 16709
Reactions
| Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable)
- Gene Name:
- araG
- Uniprot ID:
- P0AAF3
- Molecular weight:
- 55018
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable)
- Gene Name:
- mglA
- Uniprot ID:
- P0AAG8
- Molecular weight:
- 56415
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system
- Gene Name:
- pstB
- Uniprot ID:
- P0AAH0
- Molecular weight:
- 29027
Reactions
| ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In). |
- General function:
- Involved in electron carrier activity
- Specific function:
- Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds
- Gene Name:
- ynfG
- Uniprot ID:
- P0AAJ1
- Molecular weight:
- 22752
- General function:
- Involved in acylphosphatase activity
- Specific function:
- An acylphosphate + H(2)O = a carboxylate + phosphate
- Gene Name:
- yccX
- Uniprot ID:
- P0AB65
- Molecular weight:
- 10300
Reactions
| An acylphosphate + H(2)O = a carboxylate + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
- Gene Name:
- aroG
- Uniprot ID:
- P0AB91
- Molecular weight:
- 38009
Reactions
| Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. |
- General function:
- Involved in arsenate reductase (glutaredoxin) activity
- Specific function:
- Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance
- Gene Name:
- arsC
- Uniprot ID:
- P0AB96
- Molecular weight:
- 15853
Reactions
| Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O. |
- General function:
- Involved in hydrogen ion transmembrane transporter activity
- Specific function:
- Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane
- Gene Name:
- atpB
- Uniprot ID:
- P0AB98
- Molecular weight:
- 30303
- General function:
- Involved in hydrogen ion transmembrane transporter activity
- Specific function:
- Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
- Gene Name:
- atpF
- Uniprot ID:
- P0ABA0
- Molecular weight:
- 17264
- General function:
- Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism
- Specific function:
- This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction
- Gene Name:
- atpH
- Uniprot ID:
- P0ABA4
- Molecular weight:
- 19332
- General function:
- Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism
- Specific function:
- Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
- Gene Name:
- atpG
- Uniprot ID:
- P0ABA6
- Molecular weight:
- 31577
- General function:
- Involved in ATP binding
- Specific function:
- Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
- Gene Name:
- atpA
- Uniprot ID:
- P0ABB0
- Molecular weight:
- 55222
Reactions
| ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
- Gene Name:
- atpD
- Uniprot ID:
- P0ABB4
- Molecular weight:
- 50325
Reactions
| ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). |
- General function:
- Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
- Specific function:
- Mediates magnesium influx to the cytosol
- Gene Name:
- mgtA
- Uniprot ID:
- P0ABB8
- Molecular weight:
- 99466
Reactions
| ATP + H(2)O + Mg(2+)(Out) = ADP + phosphate + Mg(2+)(In). |
- General function:
- Involved in carbonate dehydratase activity
- Specific function:
- Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (cynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate
- Gene Name:
- cynT
- Uniprot ID:
- P0ABE9
- Molecular weight:
- 23764
Reactions
| H(2)CO(3) = CO(2) + H(2)O. |
- General function:
- Involved in zinc ion binding
- Specific function:
- This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
- Gene Name:
- cdd
- Uniprot ID:
- P0ABF6
- Molecular weight:
- 31539
Reactions
| Cytidine + H(2)O = uridine + NH(3). |
- General function:
- Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
- Specific function:
- Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA
- Gene Name:
- gltA
- Uniprot ID:
- P0ABH7
- Molecular weight:
- 48015
Reactions
| Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA. |
- General function:
- Involved in nitrogen compound metabolic process
- Specific function:
- Plays a role in nitrite reduction
- Gene Name:
- nrfA
- Uniprot ID:
- P0ABK9
- Molecular weight:
- 53703
Reactions
| NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+). |
- General function:
- Involved in catalytic activity
- Specific function:
- Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
- Gene Name:
- menB
- Uniprot ID:
- P0ABU0
- Molecular weight:
- 31633
Reactions
| 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O. |
- General function:
- Involved in 3-deoxy-manno-octulosonate-8-phosphatase activity
- Specific function:
- Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate
- Gene Name:
- kdsC
- Uniprot ID:
- P0ABZ4
- Molecular weight:
- 19997
Reactions
| 3-deoxy-D-manno-octulosonate 8-phosphate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate. |
- General function:
- Involved in carbohydrate binding
- Specific function:
- Catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine
- Gene Name:
- frlB
- Uniprot ID:
- P0AC00
- Molecular weight:
- 38569
Reactions
| Fructoselysine 6-phosphate + H(2)O = glucose 6-phosphate + L-lysine. |
- General function:
- Involved in dihydropteroate synthase activity
- Specific function:
- DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide
- Gene Name:
- folP
- Uniprot ID:
- P0AC13
- Molecular weight:
- 30615
Reactions
| (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. |
- General function:
- Involved in lyase activity
- Specific function:
- It functions as an aerobic enzyme in the citric acid cycle. It accounts for about 80% of the fumarase activity when the bacteria grows aerobically
- Gene Name:
- fumA
- Uniprot ID:
- P0AC33
- Molecular weight:
- 60298
Reactions
| (S)-malate = fumarate + H(2)O. |
- General function:
- Involved in hydro-lyase activity
- Specific function:
- (R,R)-tartrate = oxaloacetate + H(2)O
- Gene Name:
- ttdB
- Uniprot ID:
- P0AC35
- Molecular weight:
- 22679
Reactions
| (R,R)-tartrate = oxaloacetate + H(2)O. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
- Gene Name:
- gloB
- Uniprot ID:
- P0AC84
- Molecular weight:
- 28434
Reactions
| S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate. |
- General function:
- Involved in catalytic activity
- Specific function:
- GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H(2)O
- Gene Name:
- gmd
- Uniprot ID:
- P0AC88
- Molecular weight:
- 42047
Reactions
| GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H(2)O. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen
- Gene Name:
- hemB
- Uniprot ID:
- P0ACB2
- Molecular weight:
- 35624
Reactions
| 2 5-aminolevulinate = porphobilinogen + 2 H(2)O. |
- General function:
- Involved in FMN binding
- Specific function:
- Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Does not use oxygen directly. Is coupled to the respiratory chain
- Gene Name:
- hemG
- Uniprot ID:
- P0ACB4
- Molecular weight:
- 21226
Reactions
| Protoporphyrinogen IX + 3 menaquinone = protoporphyrin IX + 3 menaquinol. |
- General function:
- Involved in protein tyrosine phosphatase activity
- Specific function:
- Dephosphorylates etk
- Gene Name:
- etp
- Uniprot ID:
- P0ACZ2
- Molecular weight:
- 16386
Reactions
| Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. |
- General function:
- Involved in penicillin binding
- Specific function:
- Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates
- Gene Name:
- ftsI
- Uniprot ID:
- P0AD68
- Molecular weight:
- 63877
Reactions
| (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Hydrolyzes only long chain acyl thioesters (C12-C18). Specificity similar to chymotrypsin
- Gene Name:
- tesA
- Uniprot ID:
- P0ADA1
- Molecular weight:
- 23622
Reactions
| 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. |
- General function:
- Involved in phosphogluconate dehydratase activity
- Specific function:
- 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6- phospho-D-gluconate + H(2)O
- Gene Name:
- edd
- Uniprot ID:
- P0ADF6
- Molecular weight:
- 64639
Reactions
| 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O. |
- General function:
- Involved in phosphatidylinositol phosphorylation
- Specific function:
- Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
- Gene Name:
- suhB
- Uniprot ID:
- P0ADG4
- Molecular weight:
- 29172
Reactions
| Myo-inositol phosphate + H(2)O = myo-inositol + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
- Gene Name:
- guaB
- Uniprot ID:
- P0ADG7
- Molecular weight:
- 52022
Reactions
| Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH. |
- General function:
- Involved in isochorismatase activity
- Specific function:
- Required for production of 2,3-DHB. Also serves as an aryl carrier protein and plays a role in enterobactin assembly
- Gene Name:
- entB
- Uniprot ID:
- P0ADI4
- Molecular weight:
- 32554
Reactions
| Isochorismate + H(2)O = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate. |
- General function:
- Involved in peroxiredoxin activity
- Specific function:
- Directly reduces organic hydroperoxides in its reduced dithiol form
- Gene Name:
- ahpC
- Uniprot ID:
- P0AE08
- Molecular weight:
- 20761
Reactions
| 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. |
- General function:
- Involved in catalytic activity
- Specific function:
- Involved in regulation of AMP concentrations
- Gene Name:
- amn
- Uniprot ID:
- P0AE12
- Molecular weight:
- 53994
Reactions
| AMP + H(2)O = D-ribose 5-phosphate + adenine. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters
- Gene Name:
- aphA
- Uniprot ID:
- P0AE22
- Molecular weight:
- 26103
Reactions
| A phosphate monoester + H(2)O = an alcohol + phosphate. |
- General function:
- Involved in antioxidant activity
- Specific function:
- 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH
- Gene Name:
- bcp
- Uniprot ID:
- P0AE52
- Molecular weight:
- 17634
Reactions
| 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. |
- General function:
- Involved in metallopeptidase activity
- Specific function:
- Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
- Gene Name:
- dapE
- Uniprot ID:
- P0AED7
- Molecular weight:
- 41269
Reactions
| N-succinyl-LL-2,6-diaminoheptanedioate + H(2)O = succinate + LL-2,6-diaminoheptanedioate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P), and hydrolysis of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). Can hydrolyze other substrates such as MeO-HMP-PP, CF(3)-HMP-PP and MeO-TPP. Is also a non-specific nucleoside tri- and diphosphatase that releases inorganic orthophosphate
- Gene Name:
- nudJ
- Uniprot ID:
- P0AEI6
- Molecular weight:
- 17433
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduces the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator
- Gene Name:
- fre
- Uniprot ID:
- P0AEN1
- Molecular weight:
- 26242
Reactions
| Reduced riboflavin + NAD(P)(+) = riboflavin + NAD(P)H. |
| 2 cob(II)alamin + NAD(+) = 2 aquacob(III)alamin + NADH. |
- General function:
- Amino acid transport and metabolism
- Specific function:
- Catalyzes the formation of an amide bond between glutathione and spermidine coupled with hydrolysis of ATP; also catalyzes the hydrolysis of glutathionylspermidine to glutathione and spermidine
- Gene Name:
- gsp
- Uniprot ID:
- P0AES0
- Molecular weight:
- 70531
Reactions
| Glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate. |
| Glutathionylspermidine + H(2)O = glutathione + spermidine. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Catalyzes the dehydration of glucarate to 5-keto-4- deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate
- Gene Name:
- gudD
- Uniprot ID:
- P0AES2
- Molecular weight:
- 49141
Reactions
| D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O. |
- General function:
- Involved in nucleoside-triphosphate diphosphatase activity
- Specific function:
- Specific function unknown
- Gene Name:
- mazG
- Uniprot ID:
- P0AEY3
- Molecular weight:
- 30412
Reactions
| ATP + H(2)O = AMP + diphosphate. |
- General function:
- Involved in adenosylhomocysteine nucleosidase activity
- Specific function:
- Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n- butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza- adenosylhomocysteine as substrates
- Gene Name:
- mtnN
- Uniprot ID:
- P0AF12
- Molecular weight:
- 24354
Reactions
| S-adenosyl-L-homocysteine + H(2)O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine. |
| S-methyl-5'-thioadenosine + H(2)O = S-methyl-5-thio-D-ribose + adenine. |
- General function:
- Involved in hydrolase activity
- Specific function:
- N-acetyl-D-glucosamine 6-phosphate + H(2)O = D-glucosamine 6-phosphate + acetate
- Gene Name:
- nagA
- Uniprot ID:
- P0AF18
- Molecular weight:
- 40949
Reactions
| N-acetyl-D-glucosamine 6-phosphate + H(2)O = D-glucosamine 6-phosphate + acetate. |
- General function:
- Involved in nitrate reductase activity
- Specific function:
- This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit
- Gene Name:
- narV
- Uniprot ID:
- P0AF32
- Molecular weight:
- 26018
Reactions
| Nitrite + acceptor = nitrate + reduced acceptor. |
- General function:
- Involved in dATP pyrophosphohydrolase activity
- Specific function:
- Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP
- Gene Name:
- nudB
- Uniprot ID:
- P0AFC0
- Molecular weight:
- 17306
- General function:
- Involved in magnesium ion binding
- Specific function:
- Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate
- Gene Name:
- ppx
- Uniprot ID:
- P0AFL6
- Molecular weight:
- 58136
Reactions
| (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. |
- General function:
- Involved in riboflavin synthase activity
- Specific function:
- Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)- pyrimidinedione
- Gene Name:
- ribE
- Uniprot ID:
- P0AFU8
- Molecular weight:
- 23445
Reactions
| 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. |
- General function:
- Involved in amidophosphoribosyltransferase activity
- Specific function:
- 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O
- Gene Name:
- purF
- Uniprot ID:
- P0AG16
- Molecular weight:
- 56488
Reactions
| 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O. |
- General function:
- Involved in catalytic activity
- Specific function:
- In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c- di-GMP induces it
- Gene Name:
- spoT
- Uniprot ID:
- P0AG24
- Molecular weight:
- 79342
Reactions
| ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. |
| Guanosine 3',5'-bis(diphosphate) + H(2)O = guanosine 5'-diphosphate + diphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate
- Gene Name:
- serB
- Uniprot ID:
- P0AGB0
- Molecular weight:
- 35042
Reactions
| O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate. |
- General function:
- Involved in electron carrier activity
- Specific function:
- Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin
- Gene Name:
- trxC
- Uniprot ID:
- P0AGG4
- Molecular weight:
- 15555
Reactions
| Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H. |
- General function:
- Involved in serine-type endopeptidase activity
- Specific function:
- Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein
- Gene Name:
- mepA
- Uniprot ID:
- P0C0T5
- Molecular weight:
- 30136
Reactions
| Splits the D-alanyl-gamma-meso-2,6-diamino-pimelyl peptide bond connecting neighboring peptidoglycan strands. |
- General function:
- Involved in electron carrier activity
- Specific function:
- Catalyzes the oxidation of L-aspartate to iminoaspartate
- Gene Name:
- nadB
- Uniprot ID:
- P10902
- Molecular weight:
- 60337
Reactions
| L-aspartate + O(2) = iminosuccinate + H(2)O(2). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters
- Gene Name:
- ugpC
- Uniprot ID:
- P10907
- Molecular weight:
- 39524
Reactions
| ATP + H(2)O + glycerol-3-phosphate(Out) = ADP + phosphate + glycerol-3-phosphate(In). |
- General function:
- Involved in glycerophosphodiester phosphodiesterase activity
- Specific function:
- Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols
- Gene Name:
- ugpQ
- Uniprot ID:
- P10908
- Molecular weight:
- 27409
Reactions
| A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate. |
- General function:
- Involved in iron-sulfur cluster binding
- Specific function:
- The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit
- Gene Name:
- narH
- Uniprot ID:
- P11349
- Molecular weight:
- 58066
Reactions
| Nitrite + acceptor = nitrate + reduced acceptor. |
- General function:
- Involved in nitrate reductase activity
- Specific function:
- The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit
- Gene Name:
- narI
- Uniprot ID:
- P11350
- Molecular weight:
- 25497
Reactions
| Nitrite + acceptor = nitrate + reduced acceptor. |
- General function:
- Involved in quinolinate synthetase A activity
- Specific function:
- Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
- Gene Name:
- nadA
- Uniprot ID:
- P11458
- Molecular weight:
- 38240
Reactions
| Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate. |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Can hydrolyze salicin and arbutin
- Gene Name:
- bglB
- Uniprot ID:
- P11988
- Molecular weight:
- 53161
Reactions
| 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate. |
- General function:
- Involved in biotin biosynthetic process
- Specific function:
- Shows carboxylesterase activity with a preference for short chain fatty acid esters (acyl chain length of up to 6 carbons). Also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic acid into pimeloyl-CoA, a precursor in biotin biosynthesis
- Gene Name:
- bioH
- Uniprot ID:
- P13001
- Molecular weight:
- 28505
Reactions
| Pimelyl-[acyl-carrier protein] methyl ester + H(2)O = pimelyl-[acyl-carrier protein] + methanol. |
- General function:
- Involved in catalase activity
- Specific function:
- Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity. Displays also NADH oxidase, INH lyase and isonicotinoyl-NAD synthase activity
- Gene Name:
- katG
- Uniprot ID:
- P13029
- Molecular weight:
- 80023
Reactions
| Donor + H(2)O(2) = oxidized donor + 2 H(2)O. |
| 2 H(2)O(2) = O(2) + 2 H(2)O. |
- General function:
- Involved in iron ion binding
- Specific function:
- Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use
- Gene Name:
- fes
- Uniprot ID:
- P13039
- Molecular weight:
- 42569
- General function:
- Involved in catalytic activity
- Specific function:
- Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
- Gene Name:
- treA
- Uniprot ID:
- P13482
- Molecular weight:
- 63636
Reactions
| Alpha,alpha-trehalose + H(2)O = 2 D-glucose. |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Bifunctional enzyme with lysozyme/chitinase activity
- Gene Name:
- chiA
- Uniprot ID:
- P13656
- Molecular weight:
- 97057
Reactions
| Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. |
| Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline
- Gene Name:
- proV
- Uniprot ID:
- P14175
- Molecular weight:
- 44162
- General function:
- Involved in lyase activity
- Specific function:
- It functions in the generation of fumarate for use as an anaerobic electron acceptor
- Gene Name:
- fumB
- Uniprot ID:
- P14407
- Molecular weight:
- 60105
Reactions
| (S)-malate = fumarate + H(2)O. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system
- Gene Name:
- fecE
- Uniprot ID:
- P15031
- Molecular weight:
- 28191
- General function:
- Involved in DNA ligase (NAD+) activity
- Specific function:
- DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
- Gene Name:
- ligA
- Uniprot ID:
- P15042
- Molecular weight:
- 73605
Reactions
| NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)(n+m). |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate
- Gene Name:
- purL
- Uniprot ID:
- P15254
- Molecular weight:
- 141402
Reactions
| ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source
- Gene Name:
- pepD
- Uniprot ID:
- P15288
- Molecular weight:
- 52915
Reactions
| Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. |
- General function:
- Involved in IMP cyclohydrolase activity
- Specific function:
- 10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
- Gene Name:
- purH
- Uniprot ID:
- P15639
- Molecular weight:
- 57329
Reactions
| 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. |
| IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs
- Gene Name:
- dgt
- Uniprot ID:
- P15723
- Molecular weight:
- 59382
Reactions
| dGTP + H(2)O = deoxyguanosine + triphosphate. |
- General function:
- Involved in oxidoreductase activity, acting on CH-OH group of donors
- Specific function:
- GDH is probably involved in energy conservation rather than in sugar metabolism
- Gene Name:
- gcd
- Uniprot ID:
- P15877
- Molecular weight:
- 86747
Reactions
| D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol. |
- General function:
- Involved in L-serine ammonia-lyase activity
- Specific function:
- Deaminates also threonine, particularly when it is present in high concentration
- Gene Name:
- sdaA
- Uniprot ID:
- P16095
- Molecular weight:
- 48906
Reactions
| L-serine = pyruvate + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- Synthesizes selenophosphate from selenide and ATP
- Gene Name:
- selD
- Uniprot ID:
- P16456
- Molecular weight:
- 36687
Reactions
| ATP + selenide + H(2)O = AMP + selenophosphate + phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system
- Gene Name:
- cysA
- Uniprot ID:
- P16676
- Molecular weight:
- 41059
Reactions
| ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In). |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Hydrolyzes a wide variety of P-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, gentiobiose-6P, methyl- beta-glucoside-6P and p-nitrophenyl-beta-D-glucopyranoside-6P. Is also able to hydrolyze phospho-N,N'-diacetylchitobiose
- Gene Name:
- chbF
- Uniprot ID:
- P17411
- Molecular weight:
- 50512
Reactions
| 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH
- Gene Name:
- betB
- Uniprot ID:
- P17445
- Molecular weight:
- 52911
Reactions
| Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH. |
- General function:
- Involved in sulfite reductase (NADPH) activity
- Specific function:
- Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
- Gene Name:
- cysI
- Uniprot ID:
- P17846
- Molecular weight:
- 63998
Reactions
| H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH. |
- General function:
- Involved in nicotinate phosphoribosyltransferase activity
- Specific function:
- Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate
- Gene Name:
- pncB
- Uniprot ID:
- P18133
- Molecular weight:
- 45897
Reactions
| Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in phosphatidylglycerophosphatase activity
- Specific function:
- One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate
- Gene Name:
- pgpA
- Uniprot ID:
- P18200
- Molecular weight:
- 19418
Reactions
| Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. |
- General function:
- Involved in dimethyl sulfoxide reductase activity
- Specific function:
- Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant
- Gene Name:
- dmsA
- Uniprot ID:
- P18775
- Molecular weight:
- 90398
Reactions
| Dimethylsulfide + menaquinone + H(2)O = dimethylsulfoxide + menaquinol. |
- General function:
- Involved in electron carrier activity
- Specific function:
- Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds
- Gene Name:
- dmsB
- Uniprot ID:
- P18776
- Molecular weight:
- 22869
- General function:
- Involved in NAD+ synthase (glutamine-hydrolyzing) activity
- Specific function:
- Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction
- Gene Name:
- nadE
- Uniprot ID:
- P18843
- Molecular weight:
- 30637
Reactions
| ATP + deamido-NAD(+) + NH(3) = AMP + diphosphate + NAD(+). |
- General function:
- Involved in gamma-glutamyltransferase activity
- Specific function:
- (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid
- Gene Name:
- ggt
- Uniprot ID:
- P18956
- Molecular weight:
- 61768
Reactions
| A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid. |
| Glutathione + H(2)O = L-cysteinylglycine + L-glutamate. |
- General function:
- Involved in unfolded protein binding
- Specific function:
- Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 2
- Gene Name:
- narW
- Uniprot ID:
- P19317
- Molecular weight:
- 26160
- General function:
- Involved in iron-sulfur cluster binding
- Specific function:
- This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit
- Gene Name:
- narY
- Uniprot ID:
- P19318
- Molecular weight:
- 58557
Reactions
| Nitrite + acceptor = nitrate + reduced acceptor. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- The alpha chain is the actual site of nitrate reduction
- Gene Name:
- narZ
- Uniprot ID:
- P19319
- Molecular weight:
- 140226
Reactions
| Nitrite + acceptor = nitrate + reduced acceptor. |
- General function:
- Involved in 4-hydroxythreonine-4-phosphate dehydrogenase activity
- Specific function:
- Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
- Gene Name:
- pdxA
- Uniprot ID:
- P19624
- Molecular weight:
- 35114
Reactions
| 4-(phosphonooxy)-L-threonine + NAD(+) = (2S)-2-amino-3-oxo-4-phosphonooxybutanoate + NADH. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source
- Gene Name:
- agp
- Uniprot ID:
- P19926
- Molecular weight:
- 45683
Reactions
| Alpha-D-glucose 1-phosphate + H(2)O = D-glucose + phosphate. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin
- Gene Name:
- bisC
- Uniprot ID:
- P20099
- Molecular weight:
- 85850
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + sulfate = diphosphate + adenylyl sulfate
- Gene Name:
- cysD
- Uniprot ID:
- P21156
- Molecular weight:
- 35188
Reactions
| ATP + sulfate = diphosphate + adenylyl sulfate. |
- General function:
- Involved in cellular process
- Specific function:
- Splits dipeptides with a prolyl residue in the C- terminal position and a polar or nonpolar amino acid at the N- terminal position. With much lower efficiency, also catalyzes the stereoselective hydrolysis of a wide variety of organophosphate triesters and organophosphonate diesters. Is able to hydrolyze the organophosphorus insecticide paraoxon and the p-nitrophenyl analogs of the nerve agents GB (sarin), GD (soman), GF, Vx and rVX
- Gene Name:
- pepQ
- Uniprot ID:
- P21165
- Molecular weight:
- 50176
Reactions
| Hydrolysis of Xaa-|-Pro dipeptides |
| also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro. |
- General function:
- Involved in 3-hydroxyacyl-CoA dehydrogenase activity
- Specific function:
- Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities. Involved in the aerobic and anaerobic degradation of long-chain fatty acids
- Gene Name:
- fadB
- Uniprot ID:
- P21177
- Molecular weight:
- 79593
Reactions
| (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. |
| (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. |
| (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. |
| (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA. |
- General function:
- Involved in catalase activity
- Specific function:
- Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide
- Gene Name:
- katE
- Uniprot ID:
- P21179
- Molecular weight:
- 84162
Reactions
| 2 H(2)O(2) = O(2) + 2 H(2)O. |
- General function:
- Involved in catalytic activity
- Specific function:
- Nicotinamide + H(2)O = nicotinate + NH(3)
- Gene Name:
- pncA
- Uniprot ID:
- P21369
- Molecular weight:
- 23362
Reactions
| Nicotinamide + H(2)O = nicotinate + NH(3). |
- General function:
- Involved in two-component response regulator activity
- Specific function:
- Hydrolyzes c-di-GMP (cyclic bis(3'-5') dimeric GMP) to 5'-pGpG, known as PDE-A activity. PDE-B activity, that is hydrolysis of 5'-pGpG to GMP, proceeds only very slowly
- Gene Name:
- yahA
- Uniprot ID:
- P21514
- Molecular weight:
- 40725
- General function:
- Involved in [acyl-carrier-protein] phosphodiesterase activity
- Specific function:
- Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
- Gene Name:
- acpH
- Uniprot ID:
- P21515
- Molecular weight:
- 22961
Reactions
| Holo-[acyl-carrier-protein] + H(2)O = 4'-phosphopantetheine + apo-[acyl-carrier-protein]. |
- General function:
- Involved in catalytic activity
- Specific function:
- May play a role in regulating the intracellular level of maltotriose. Cleaves glucose from the reducing end of maltotriose and longer maltodextrins with a chain length of up to 7 glucose units
- Gene Name:
- malZ
- Uniprot ID:
- P21517
- Molecular weight:
- 69172
Reactions
| Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates pyridoxalphosphate and erythrose 4-phosphate
- Gene Name:
- ybhA
- Uniprot ID:
- P21829
- Molecular weight:
- 30201
- General function:
- Involved in asparagine synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
- Gene Name:
- asnB
- Uniprot ID:
- P22106
- Molecular weight:
- 62659
Reactions
| ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2)
- Gene Name:
- cysQ
- Uniprot ID:
- P22255
- Molecular weight:
- 27176
Reactions
| Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate. |
- General function:
- Involved in deaminase activity
- Specific function:
- Adenosine + H(2)O = inosine + NH(3)
- Gene Name:
- add
- Uniprot ID:
- P22333
- Molecular weight:
- 36397
Reactions
| Adenosine + H(2)O = inosine + NH(3). |
- General function:
- Involved in hydrolase activity, hydrolyzing N-glycosyl compounds
- Specific function:
- Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, cytidine, guanosine
- Gene Name:
- rihC
- Uniprot ID:
- P22564
- Molecular weight:
- 32560
- General function:
- Involved in transferase activity
- Specific function:
- Acts as a beta-cystathionase and as a repressor of the maltose regulon
- Gene Name:
- malY
- Uniprot ID:
- P23256
- Molecular weight:
- 43641
Reactions
| L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
- Gene Name:
- ppsA
- Uniprot ID:
- P23538
- Molecular weight:
- 87434
Reactions
| ATP + pyruvate + H(2)O = AMP + phosphoenolpyruvate + phosphate. |
- General function:
- Involved in GTPase activity
- Specific function:
- May be the GTPase, regulating ATP sulfurylase activity
- Gene Name:
- cysN
- Uniprot ID:
- P23845
- Molecular weight:
- 52558
Reactions
| ATP + sulfate = diphosphate + adenylyl sulfate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system
- Gene Name:
- fepC
- Uniprot ID:
- P23878
- Molecular weight:
- 29784
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Involved in the breakdown of putrescine. Was previously shown to have a weak but measurable ALDH enzyme activity that prefers NADP over NAD as coenzyme
- Gene Name:
- puuC
- Uniprot ID:
- P23883
- Molecular weight:
- 53418
Reactions
| Gamma-glutamyl-gamma-aminobutyraldehyde + NAD(+) + H(2)O = gamma-glutamyl-gamma-aminobutyrate + NADH. |
| An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H. |
- General function:
- Involved in zinc ion binding
- Specific function:
- Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde
- Gene Name:
- argE
- Uniprot ID:
- P23908
- Molecular weight:
- 42347
Reactions
| N(2)-acetyl-L-ornithine + H(2)O = acetate + L-ornithine. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate. This enzyme is specific for NADP
- Gene Name:
- folD
- Uniprot ID:
- P24186
- Molecular weight:
- 31044
Reactions
| 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH. |
| 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate. |
- General function:
- Involved in mannonate dehydratase activity
- Specific function:
- D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O
- Gene Name:
- uxuA
- Uniprot ID:
- P24215
- Molecular weight:
- 44838
Reactions
| D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Can hydrolyze salicin, cellobiose, and probably arbutin
- Gene Name:
- ascB
- Uniprot ID:
- P24240
- Molecular weight:
- 53935
Reactions
| 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate. |
- General function:
- Involved in zinc ion binding
- Specific function:
- Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates
- Gene Name:
- frmA
- Uniprot ID:
- P25437
- Molecular weight:
- 39359
Reactions
| S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H. |
| An alcohol + NAD(+) = an aldehyde or ketone + NADH. |
- General function:
- Involved in metabolic process
- Specific function:
- May have an iron-responsive regulatory function
- Gene Name:
- acnA
- Uniprot ID:
- P25516
- Molecular weight:
- 97676
Reactions
| Citrate = isocitrate. |
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
- Specific function:
- Cytosine + H(2)O = uracil + NH(3)
- Gene Name:
- codA
- Uniprot ID:
- P25524
- Molecular weight:
- 47591
Reactions
| Cytosine + H(2)O = uracil + NH(3). |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H
- Gene Name:
- gabD
- Uniprot ID:
- P25526
- Molecular weight:
- 51720
Reactions
| Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
- Gene Name:
- ribD
- Uniprot ID:
- P25539
- Molecular weight:
- 40338
Reactions
| 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-phosphoribosylamino)uracil + NH(3). |
| 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH. |
- General function:
- Involved in catalytic activity
- Specific function:
- A phenol sulfate + H(2)O = a phenol + sulfate
- Gene Name:
- aslA
- Uniprot ID:
- P25549
- Molecular weight:
- 60717
Reactions
| A phenol sulfate + H(2)O = a phenol + sulfate. |
- General function:
- Involved in guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
- Specific function:
- Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities
- Gene Name:
- gppA
- Uniprot ID:
- P25552
- Molecular weight:
- 54871
Reactions
| Guanosine 5'-triphosphate,3'-diphosphate + H(2)O = guanosine 3',5'-bis(diphosphate) + phosphate. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Acts on lactaldehyde as well as other aldehydes
- Gene Name:
- aldA
- Uniprot ID:
- P25553
- Molecular weight:
- 52272
Reactions
| (S)-lactaldehyde + NAD(+) + H(2)O = (S)-lactate + NADH. |
| Glycolaldehyde + NAD(+) + H(2)O = glycolate + NADH. |
- General function:
- Involved in catalytic activity
- Specific function:
- Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, malF, malG, and malK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the malS protein
- Gene Name:
- malS
- Uniprot ID:
- P25718
- Molecular weight:
- 75712
Reactions
| Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units. |
- General function:
- Involved in N-acetylmuramoyl-L-alanine amidase activity
- Specific function:
- Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling
- Gene Name:
- amiB
- Uniprot ID:
- P26365
- Molecular weight:
- 47985
Reactions
| Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides
- Gene Name:
- amyA
- Uniprot ID:
- P26612
- Molecular weight:
- 56639
Reactions
| Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units. |
- General function:
- Involved in aminomethyltransferase activity
- Specific function:
- The glycine cleavage system catalyzes the degradation of glycine
- Gene Name:
- gcvT
- Uniprot ID:
- P27248
- Molecular weight:
- 40146
Reactions
| [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3). |
- General function:
- Involved in UDP-N-acetylglucosamine 2-epimerase activity
- Specific function:
- Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption
- Gene Name:
- wecB
- Uniprot ID:
- P27828
- Molecular weight:
- 42244
Reactions
| UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. |
- General function:
- Involved in oxidation-reduction process
- Specific function:
- Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA)
- Gene Name:
- wecC
- Uniprot ID:
- P27829
- Molecular weight:
- 45838
Reactions
| UDP-N-acetyl-D-mannosamine + 2 NAD(+) + H(2)O = UDP-N-acetyl-D-mannosaminuronate + 2 NADH. |
- General function:
- Involved in dTDP-glucose 4,6-dehydratase activity
- Specific function:
- Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction
- Gene Name:
- rffG
- Uniprot ID:
- P27830
- Molecular weight:
- 39754
Reactions
| dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H(2)O. |
- General function:
- Involved in dCTP deaminase activity
- Specific function:
- dCTP + H(2)O = dUTP + NH(3)
- Gene Name:
- dcd
- Uniprot ID:
- P28248
- Molecular weight:
- 21249
Reactions
| dCTP + H(2)O = dUTP + NH(3). |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Transports electrons between flavodoxin or ferredoxin and NADPH. Involved in the reductive activation of cobalamin- independent methionine synthase, pyruvate formate lyase and anaerobic ribonucleotide reductase. Also protects against superoxide radicals due to methyl viologen in the presence of oxygen
- Gene Name:
- fpr
- Uniprot ID:
- P28861
- Molecular weight:
- 27751
Reactions
| 2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH. |
- General function:
- Involved in catalytic activity
- Specific function:
- 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin
- Gene Name:
- nrdD
- Uniprot ID:
- P28903
- Molecular weight:
- 80022
Reactions
| 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin. |
- General function:
- Involved in catalytic activity
- Specific function:
- Alpha,alpha-trehalose 6-phosphate + H(2)O = D- glucose + D-glucose 6-phosphate
- Gene Name:
- treC
- Uniprot ID:
- P28904
- Molecular weight:
- 63837
Reactions
| Alpha,alpha-trehalose 6-phosphate + H(2)O = D-glucose + D-glucose 6-phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Converts SHCHC to OSB
- Gene Name:
- menC
- Uniprot ID:
- P29208
- Molecular weight:
- 35476
Reactions
| (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H(2)O. |
- General function:
- Involved in 3-isopropylmalate dehydratase activity
- Specific function:
- Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
- Gene Name:
- leuD
- Uniprot ID:
- P30126
- Molecular weight:
- 22487
Reactions
| (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmaleate + H(2)O. |
| (2S)-2-isopropylmaleate + H(2)O = (2S)-2-isopropylmalate. |
- General function:
- Involved in L-serine ammonia-lyase activity
- Specific function:
- Deaminates also threonine, particularly when it is present in high concentration
- Gene Name:
- sdaB
- Uniprot ID:
- P30744
- Molecular weight:
- 48753
Reactions
| L-serine = pyruvate + NH(3). |
- General function:
- Involved in Mo-molybdopterin cofactor biosynthetic process
- Specific function:
- Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
- Gene Name:
- moaD
- Uniprot ID:
- P30748
- Molecular weight:
- 8758
- General function:
- Involved in Mo-molybdopterin cofactor biosynthetic process
- Specific function:
- Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD
- Gene Name:
- moaE
- Uniprot ID:
- P30749
- Molecular weight:
- 16981
Reactions
| Cyclic pyranopterin monophosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H(2)O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]. |
- General function:
- Involved in 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
- Specific function:
- Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate
- Gene Name:
- panB
- Uniprot ID:
- P31057
- Molecular weight:
- 28237
Reactions
| 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate. |
- General function:
- Involved in adenine deaminase activity
- Specific function:
- Adenine + H(2)O = hypoxanthine + NH(3)
- Gene Name:
- ade
- Uniprot ID:
- P31441
- Molecular weight:
- 63739
Reactions
| Adenine + H(2)O = hypoxanthine + NH(3). |
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- metI
- Uniprot ID:
- P31547
- Molecular weight:
- 23256
- General function:
- Involved in hydro-lyase activity
- Specific function:
- Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
- Gene Name:
- caiD
- Uniprot ID:
- P31551
- Molecular weight:
- 28190
Reactions
| L-carnitinyl-CoA = H(2)O + crotonobetainyl-CoA. |
- General function:
- Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
- Specific function:
- Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity
- Gene Name:
- prpC
- Uniprot ID:
- P31660
- Molecular weight:
- 43102
Reactions
| Propanoyl-CoA + H(2)O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Removes the phosphate from trehalose 6-phosphate to produce free trehalose
- Gene Name:
- otsB
- Uniprot ID:
- P31678
- Molecular weight:
- 29175
Reactions
| Trehalose 6-phosphate + H(2)O = trehalose + phosphate. |
- General function:
- Involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- Specific function:
- Could participate in the regulation of cell wall biosynthesis by influencing the concentration of GDP-mannose or GDP-glucose in the cell. May be involved in the degradation of GDP-mannose and GDP-glucose, diverting the GDP to the synthesis of GDP-fucose as required. Might also be involved in the biosynthesis of the slime polysaccharide colanic acid
- Gene Name:
- nudD
- Uniprot ID:
- P32056
- Molecular weight:
- 18273
Reactions
| GDP-D-mannose + H(2)O = GDP + D-mannose. |
- General function:
- Involved in catalytic activity
- Specific function:
- Exhibits hydrolysis activity against alpha-glucosyl fluoride, although natural substrates, such as alpha-glucobioses are scarcely hydrolyzed
- Gene Name:
- yihQ
- Uniprot ID:
- P32138
- Molecular weight:
- 77274
Reactions
| Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. |
- General function:
- Involved in catalytic activity
- Specific function:
- Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress
- Gene Name:
- gph
- Uniprot ID:
- P32662
- Molecular weight:
- 27389
Reactions
| 2-phosphoglycolate + H(2)O = glycolate + phosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- NAD(+) + H(2)O = AMP + NMN
- Gene Name:
- nudC
- Uniprot ID:
- P32664
- Molecular weight:
- 29689
Reactions
| NAD(+) + H(2)O = AMP + NMN. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system
- Gene Name:
- alsA
- Uniprot ID:
- P32721
- Molecular weight:
- 56744
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in carboxylesterase activity
- Specific function:
- Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids
- Gene Name:
- yeiG
- Uniprot ID:
- P33018
- Molecular weight:
- 31259
Reactions
| S-formylglutathione + H(2)O = glutathione + formate. |
- General function:
- Involved in hydrolase activity, hydrolyzing N-glycosyl compounds
- Specific function:
- Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine
- Gene Name:
- rihB
- Uniprot ID:
- P33022
- Molecular weight:
- 33748
Reactions
| A pyrimidine nucleoside + H(2)O = D-ribose + a pyrimidine base. |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP
- Gene Name:
- purT
- Uniprot ID:
- P33221
- Molecular weight:
- 42433
Reactions
| Formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate. |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Hydrolysis of terminal, non-reducing beta-D- glucosyl residues with release of beta-D-glucose
- Gene Name:
- bglX
- Uniprot ID:
- P33363
- Molecular weight:
- 83459
Reactions
| Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system
- Gene Name:
- ccmA
- Uniprot ID:
- P33931
- Molecular weight:
- 23053
Reactions
| ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out). |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein napC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism
- Gene Name:
- napA
- Uniprot ID:
- P33937
- Molecular weight:
- 93041
Reactions
| Nitrite + acceptor = nitrate + reduced acceptor. |
- General function:
- Involved in N-acetylmuramoyl-L-alanine amidase activity
- Specific function:
- Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides
- Gene Name:
- amiA
- Uniprot ID:
- P36548
- Molecular weight:
- 31412
Reactions
| Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. |
- General function:
- Involved in coproporphyrinogen oxidase activity
- Specific function:
- Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III
- Gene Name:
- hemF
- Uniprot ID:
- P36553
- Molecular weight:
- 34322
Reactions
| Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm
- Gene Name:
- cueO
- Uniprot ID:
- P36649
- Molecular weight:
- 56556
- General function:
- Involved in metabolic process
- Specific function:
- Citrate = isocitrate
- Gene Name:
- acnB
- Uniprot ID:
- P36683
- Molecular weight:
- 93497
Reactions
| Citrate = isocitrate. |
| (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H(2)O. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system
- Gene Name:
- fbpC
- Uniprot ID:
- P37009
- Molecular weight:
- 39059
Reactions
| ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In). |
- General function:
- Involved in amino acid binding
- Specific function:
- Produces formate from formyl-tetrahydrofolate. Provides the major source of formate for the purT-dependent synthesis of 5'-phosphoribosyl-N-formylglycinamide (FGAR) during aerobic growth. Has a role in regulating the one-carbon pool
- Gene Name:
- purU
- Uniprot ID:
- P37051
- Molecular weight:
- 31934
Reactions
| 10-formyltetrahydrofolate + H(2)O = formate + tetrahydrofolate. |
- General function:
- Involved in aminopeptidase activity
- Specific function:
- Probably plays an important role in intracellular peptide degradation
- Gene Name:
- pepB
- Uniprot ID:
- P37095
- Molecular weight:
- 46180
Reactions
| Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis
- Gene Name:
- nrdF
- Uniprot ID:
- P37146
- Molecular weight:
- 36443
Reactions
| 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. |
- General function:
- Involved in electron carrier activity
- Specific function:
- 2 ferrocytochrome c + H(2)O(2) = 2 ferricytochrome c + 2 H(2)O
- Gene Name:
- yhjA
- Uniprot ID:
- P37197
- Molecular weight:
- 51570
Reactions
| 2 ferrocytochrome c + H(2)O(2) = 2 ferricytochrome c + 2 H(2)O. |
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate
- Gene Name:
- arcC
- Uniprot ID:
- P37306
- Molecular weight:
- 31644
Reactions
| ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Accounts for almost the entire malate-synthesizing activity in cells metabolizing glyoxylate
- Gene Name:
- glcB
- Uniprot ID:
- P37330
- Molecular weight:
- 80488
Reactions
| Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose
- Gene Name:
- xylG
- Uniprot ID:
- P37388
- Molecular weight:
- 56470
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in hydrolase activity
- Specific function:
- May be involved in glutathione, and possibly other peptide, transport, although these results could also be due to polar effects of disruption
- Gene Name:
- iaaA
- Uniprot ID:
- P37595
- Molecular weight:
- 33394
Reactions
| Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Involved in export of lead, cadmium, zinc and mercury
- Gene Name:
- zntA
- Uniprot ID:
- P37617
- Molecular weight:
- 76839
Reactions
| ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out). |
| ATP + H(2)O + Zn(2+)(In) = ADP + phosphate + Zn(2+)(Out). |
- General function:
- Involved in catalytic activity
- Specific function:
- Hydrolyzes carboxymethylcellulose
- Gene Name:
- bcsZ
- Uniprot ID:
- P37651
- Molecular weight:
- 41700
Reactions
| Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the NADP-dependent oxidation of diverse aldehydes such as chloroacetaldehyde, acetaldehyde, propionaldehyde, benzaldehyde, mafosfamide, 4- hydroperoxycyclophosphamide. Its preferred substrates are acetaldehyde and chloroacetaldehyde
- Gene Name:
- aldB
- Uniprot ID:
- P37685
- Molecular weight:
- 56306
- General function:
- Involved in dTDP-glucose 4,6-dehydratase activity
- Specific function:
- Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction
- Gene Name:
- rfbB
- Uniprot ID:
- P37759
- Molecular weight:
- 40558
Reactions
| dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H(2)O. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine
- Gene Name:
- puuB
- Uniprot ID:
- P37906
- Molecular weight:
- 47169
Reactions
| Gamma-glutamylputrescine + H(2)O + O(2) = Gamma-glutamyl-gamma-aminobutyraldehyde + NH(3) + H(2)O(2). |
- General function:
- Involved in sulfite reductase (NADPH) activity
- Specific function:
- Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component
- Gene Name:
- cysJ
- Uniprot ID:
- P38038
- Molecular weight:
- 66269
Reactions
| H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species
- Gene Name:
- nfnB
- Uniprot ID:
- P38489
- Molecular weight:
- 23905
Reactions
| A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H. |
- General function:
- Involved in GTPase activity
- Specific function:
- May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover. Dispensible for viability, but important for overall fitness. The intrinsic GTPase activity is stimulated by the presence of 30S (160-fold increase in kcat) or 70S (96 fold increase in kcat) ribosomes (PubMed:14973029). The GTPase is inhibited by aminoglycoside antibiotics such as neomycin and paromycin (PubMed:15466596) streptomycin and spectinomycin (PubMed:15828870). This inhibition is not due to competition for binding sites on the 30S or 70S ribosome (PubMed:15828870)
- Gene Name:
- rsgA
- Uniprot ID:
- P39286
- Molecular weight:
- 39193
- General function:
- Involved in catalytic activity
- Specific function:
- Specific function unknown
- Gene Name:
- yjhH
- Uniprot ID:
- P39359
- Molecular weight:
- 32721
- General function:
- Involved in zinc ion binding
- Specific function:
- Preferred specificity is towards 1-propanol
- Gene Name:
- adhP
- Uniprot ID:
- P39451
- Molecular weight:
- 35379
Reactions
| An alcohol + NAD(+) = an aldehyde or ketone + NADH. |
- General function:
- Involved in oxidation-reduction process
- Specific function:
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1E contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide
- Gene Name:
- nrdE
- Uniprot ID:
- P39452
- Molecular weight:
- 80478
Reactions
| 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. |
- General function:
- Involved in hydro-lyase activity
- Specific function:
- D-galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O
- Gene Name:
- garD
- Uniprot ID:
- P39829
- Molecular weight:
- 56401
Reactions
| D-galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O. |
- General function:
- Involved in transaminase activity
- Specific function:
- Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine. Alpha-ketobutyrate and pyruvate can also act as amino acceptors, although much less efficiently
- Gene Name:
- patA
- Uniprot ID:
- P42588
- Molecular weight:
- 49661
Reactions
| Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H(2)O. |
- General function:
- Involved in hydro-lyase activity
- Specific function:
- D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O
- Gene Name:
- uxaA
- Uniprot ID:
- P42604
- Molecular weight:
- 54093
Reactions
| D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. |
- General function:
- Involved in L-serine ammonia-lyase activity
- Specific function:
- L-serine = pyruvate + NH(3)
- Gene Name:
- tdcG
- Uniprot ID:
- P42630
- Molecular weight:
- 48521
Reactions
| L-serine = pyruvate + NH(3). |
- General function:
- Involved in hydrolase activity
- Specific function:
- N-acetyl-D-galactosamine 6-phosphate + H(2)O = D-galactosamine 6-phosphate + acetate
- Gene Name:
- agaA
- Uniprot ID:
- P42906
- Molecular weight:
- 17519
Reactions
| N-acetyl-D-galactosamine 6-phosphate + H(2)O = D-galactosamine 6-phosphate + acetate. |
- General function:
- Involved in carbohydrate metabolic process
- Specific function:
- D-galactosamine 6-phosphate + H(2)O = D- tagatose 6-phosphate + NH(3)
- Gene Name:
- agaI
- Uniprot ID:
- P42912
- Molecular weight:
- 27724
Reactions
| D-galactosamine 6-phosphate + H(2)O = D-tagatose 6-phosphate + NH(3). |
- General function:
- Involved in hydrolase activity
- Specific function:
- Probably mediates the hydrolysis of some nucleoside diphosphate derivatives
- Gene Name:
- nudL
- Uniprot ID:
- P43337
- Molecular weight:
- 21435
- General function:
- Involved in hydrolase activity
- Specific function:
- Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP
- Gene Name:
- lpxH
- Uniprot ID:
- P43341
- Molecular weight:
- 26894
Reactions
| UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine + H(2)O = 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. |
- General function:
- Involved in pectinesterase activity
- Specific function:
- Putative thioesterase. Does not bind pectin, and has no pectinesterase activity
- Gene Name:
- ybhC
- Uniprot ID:
- P46130
- Molecular weight:
- 46082
- General function:
- Involved in copper ion binding
- Specific function:
- The enzyme prefers aromatic over aliphatic amines
- Gene Name:
- tynA
- Uniprot ID:
- P46883
- Molecular weight:
- 84378
Reactions
| RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2). |
| 2-phenylethylamine + H(2)O + O(2) = phenylacetaldehyde + NH(3) + H(2)O(2). |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and CF(3)-HMP-PP
- Gene Name:
- cof
- Uniprot ID:
- P46891
- Molecular weight:
- 30371
- General function:
- Involved in carboxylesterase activity
- Specific function:
- Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione
- Gene Name:
- frmB
- Uniprot ID:
- P51025
- Molecular weight:
- 31424
Reactions
| S-formylglutathione + H(2)O = glutathione + formate. |
- General function:
- Involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- Specific function:
- Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP)
- Gene Name:
- nudI
- Uniprot ID:
- P52006
- Molecular weight:
- 16371
Reactions
| Nucleoside triphosphate + H(2)O = nucleoside monophosphate + diphosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions
- Gene Name:
- rdgB
- Uniprot ID:
- P52061
- Molecular weight:
- 21039
Reactions
| A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin
- Gene Name:
- cobC
- Uniprot ID:
- P52086
- Molecular weight:
- 23308
Reactions
| Adenosylcobalamin 5'-phosphate + H(2)O = coenzyme B12 + phosphate. |
| Alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage
- Gene Name:
- fliI
- Uniprot ID:
- P52612
- Molecular weight:
- 49315
Reactions
| ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). |
- General function:
- Involved in 6-phosphogluconolactonase activity
- Specific function:
- Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
- Gene Name:
- pgl
- Uniprot ID:
- P52697
- Molecular weight:
- 36308
Reactions
| 6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Plays a key role in signaling protein misfolding via the cpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates
- Gene Name:
- pphA
- Uniprot ID:
- P55798
- Molecular weight:
- 25274
Reactions
| A phosphoprotein + H(2)O = a protein + phosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Has been shown, in vitro, to act on Ser, Thr and Tyr- phosphorylated substrates
- Gene Name:
- pphB
- Uniprot ID:
- P55799
- Molecular weight:
- 25098
Reactions
| A phosphoprotein + H(2)O = a protein + phosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- 4-carboxymethylenebut-2-en-4-olide + H(2)O = 4-oxohex-2-enedioate
- Gene Name:
- ysgA
- Uniprot ID:
- P56262
- Molecular weight:
- 29425
Reactions
| 4-carboxymethylenebut-2-en-4-olide + H(2)O = 4-oxohex-2-enedioate. |
- General function:
- Involved in agmatinase activity
- Specific function:
- Catalyzes the formation of putrescine from agmatine
- Gene Name:
- speB
- Uniprot ID:
- P60651
- Molecular weight:
- 33557
Reactions
| Agmatine + H(2)O = putrescine + urea. |
- General function:
- Involved in undecaprenyl-diphosphatase activity
- Specific function:
- Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
- Gene Name:
- uppP
- Uniprot ID:
- P60932
- Molecular weight:
- 29758
Reactions
| Undecaprenyl diphosphate + H(2)O = undecaprenyl phosphate + phosphate. |
- General function:
- Involved in carbonate dehydratase activity
- Specific function:
- H(2)CO(3) = CO(2) + H(2)O
- Gene Name:
- can
- Uniprot ID:
- P61517
- Molecular weight:
- 25097
Reactions
| H(2)CO(3) = CO(2) + H(2)O. |
- General function:
- Involved in riboflavin biosynthetic process
- Specific function:
- Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino- 2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4- phosphate yielding 6,7-dimethyl-8-lumazine
- Gene Name:
- ribH
- Uniprot ID:
- P61714
- Molecular weight:
- 16156
Reactions
| 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. |
- General function:
- Involved in catalytic activity
- Specific function:
- Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity
- Gene Name:
- treF
- Uniprot ID:
- P62601
- Molecular weight:
- 63696
Reactions
| Alpha,alpha-trehalose + H(2)O = 2 D-glucose. |
- General function:
- Involved in catalytic activity
- Specific function:
- Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
- Gene Name:
- ispG
- Uniprot ID:
- P62620
- Molecular weight:
- 40683
Reactions
| (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. |
- General function:
- Involved in isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
- Specific function:
- Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with relA to maintain it in an inactive form during normal growth
- Gene Name:
- ispH
- Uniprot ID:
- P62623
- Molecular weight:
- 34774
Reactions
| Isopentenyl diphosphate + NAD(P)(+) + H(2)O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. |
| Dimethylallyl diphosphate + NAD(P)(+) + H(2)O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. |
- General function:
- Involved in N-acetylmuramoyl-L-alanine amidase activity
- Specific function:
- Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling
- Gene Name:
- amiC
- Uniprot ID:
- P63883
- Molecular weight:
- 45634
Reactions
| Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP
- Gene Name:
- queD
- Uniprot ID:
- P65870
- Molecular weight:
- 13773
Reactions
| 7,8-dihydroneopterin 3'-triphosphate + H(2)O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate. |
- General function:
- Involved in diaminopropionate ammonia-lyase activity
- Specific function:
- Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate, the most suitable substrates to form pyruvate and ammonia. The L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position
- Gene Name:
- ygeX
- Uniprot ID:
- P66899
- Molecular weight:
- 43327
Reactions
| 2,3-diaminopropionate + H(2)O = pyruvate + 2 NH(3). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system
- Gene Name:
- malK
- Uniprot ID:
- P68187
- Molecular weight:
- 40990
Reactions
| ATP + H(2)O + maltose(Out) = ADP + phosphate + maltose(In). |
- General function:
- Involved in hydrogen ion transmembrane transporter activity
- Specific function:
- Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of 10 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits
- Gene Name:
- atpE
- Uniprot ID:
- P68699
- Molecular weight:
- 8256
- General function:
- Involved in aminopeptidase activity
- Specific function:
- Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place
- Gene Name:
- pepA
- Uniprot ID:
- P68767
- Molecular weight:
- 54879
Reactions
| Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. |
| Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system
- Gene Name:
- potA
- Uniprot ID:
- P69874
- Molecular weight:
- 43028
Reactions
| ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In). |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis
- Gene Name:
- nrdB
- Uniprot ID:
- P69924
- Molecular weight:
- 43517
Reactions
| 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. |
- General function:
- Involved in catalytic activity
- Specific function:
- Unknown Function
- Gene Name:
- yagE
- Uniprot ID:
- P75682
- Molecular weight:
- 33316
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
- Gene Name:
- ubiF
- Uniprot ID:
- P75728
- Molecular weight:
- 42953
- General function:
- Involved in metabolic process
- Specific function:
- Unknown Function
- Gene Name:
- ybhJ
- Uniprot ID:
- P75764
- Molecular weight:
- 81504
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of fructose-1-P most efficiently, but it remains uncertain if this is the real substrate in vivo
- Gene Name:
- supH
- Uniprot ID:
- P75792
- Molecular weight:
- 30413
Reactions
| Sugar phosphate + H(2)O = sugar + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo
- Gene Name:
- ybjG
- Uniprot ID:
- P75806
- Molecular weight:
- 22398
Reactions
| Undecaprenyl diphosphate + H(2)O = undecaprenyl phosphate + phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates FMN and beta-glucose 1-phosphate
- Gene Name:
- ybjI
- Uniprot ID:
- P75809
- Molecular weight:
- 30196
- General function:
- Involved in N-acetylmuramoyl-L-alanine amidase activity
- Specific function:
- Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides
- Gene Name:
- amiD
- Uniprot ID:
- P75820
- Molecular weight:
- 31072
Reactions
| Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. |
- General function:
- Involved in oxidoreductase activity, acting on other nitrogenous compounds as donors
- Specific function:
- Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. Is also able to reduce hydroxylamine analogs such as methylhydroxylamine and hydroxyquinone. Might have a role as a scavenger of potentially toxic by-products of nitrate metabolism
- Gene Name:
- hcp
- Uniprot ID:
- P75825
- Molecular weight:
- 60063
- General function:
- Involved in beta-N-acetylhexosaminidase activity
- Specific function:
- Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides
- Gene Name:
- nagZ
- Uniprot ID:
- P75949
- Molecular weight:
- 37594
Reactions
| Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. |
- General function:
- Defense mechanisms
- Specific function:
- Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the lcdA reaction can then be reused as peptidoglycan building blocks; lcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase
- Gene Name:
- ldcA
- Uniprot ID:
- P76008
- Molecular weight:
- 33567
Reactions
| GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H(2)O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma- aminobutyrate
- Gene Name:
- puuD
- Uniprot ID:
- P76038
- Molecular weight:
- 28013
Reactions
| 4-(L-gamma-glutamylamino)butanoate + H(2)O = 4-aminobutanoate + L-glutamate. |
- General function:
- Involved in electron carrier activity
- Specific function:
- May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation
- Gene Name:
- paaE
- Uniprot ID:
- P76081
- Molecular weight:
- 39320
- General function:
- Involved in catalytic activity
- Specific function:
- Could possibly oxidize fatty acids using specific components
- Gene Name:
- paaF
- Uniprot ID:
- P76082
- Molecular weight:
- 27237
Reactions
| (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. |
- General function:
- Involved in phosphorus-oxygen lyase activity
- Specific function:
- In association with DosC is involved in the production and removal of the second messenger c-di-GMP in response to changing O(2) levels. Has phosphodiesterase (PDE) activity with c- di-GMP (PubMed:15995192), very poor activity on cAMP (PubMed:15995192) but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate (PubMed:11970957). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
- Gene Name:
- dosP
- Uniprot ID:
- P76129
- Molecular weight:
- 90260
Reactions
| Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine. |
- General function:
- Involved in hydrolase activity, acting on ester bonds
- Specific function:
- Transforms N(2)-succinylglutamate into succinate and glutamate
- Gene Name:
- astE
- Uniprot ID:
- P76215
- Molecular weight:
- 35800
Reactions
| N-succinyl-L-glutamate + H(2)O = succinate + L-glutamate. |
- General function:
- Involved in N-succinylarginine dihydrolase activity
- Specific function:
- Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)
- Gene Name:
- astB
- Uniprot ID:
- P76216
- Molecular weight:
- 49298
Reactions
| N(2)-succinyl-L-arginine + 2 H(2)O = N(2)-succinyl-L-ornithine + 2 NH(3) + CO(2). |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. Also shows activity with decanal or succinic semialdehyde as the electron donor and NAD as the electron acceptor. No activity is detected with NADP as the electron acceptor. Therefore, is an aldehyde dehydrogenase with broad substrate specificity
- Gene Name:
- astD
- Uniprot ID:
- P76217
- Molecular weight:
- 53026
Reactions
| N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH. |
- General function:
- Involved in D-cysteine desulfhydrase activity
- Specific function:
- Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine
- Gene Name:
- dcyD
- Uniprot ID:
- P76316
- Molecular weight:
- 35153
Reactions
| D-cysteine + H(2)O = H(2)S + NH(3) + pyruvate. |
- General function:
- Involved in catalytic activity
- Specific function:
- 2(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2(alpha-D-mannosyl)-D-glycerate + phosphate
- Gene Name:
- yedP
- Uniprot ID:
- P76329
- Molecular weight:
- 30439
Reactions
| 2(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2(alpha-D-mannosyl)-D-glycerate + phosphate. |
- General function:
- Involved in oxidation-reduction process
- Specific function:
- UDP-glucose + 2 NAD(+) + H(2)O = UDP- glucuronate + 2 NADH
- Gene Name:
- ugd
- Uniprot ID:
- P76373
- Molecular weight:
- 43656
Reactions
| UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH. |
- General function:
- Involved in catalytic activity
- Specific function:
- Nucleotidase that shows strict specificity toward deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. Might be involved in the regulation of all dNTP pools in E.coli
- Gene Name:
- yfbR
- Uniprot ID:
- P76491
- Molecular weight:
- 22708
Reactions
| A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. |
- General function:
- Involved in carbon-oxygen lyase activity
- Specific function:
- Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
- Gene Name:
- murQ
- Uniprot ID:
- P76535
- Molecular weight:
- 31220
Reactions
| N-acetylmuramate 6-phosphate + H(2)O = N-acetyl-D-glucosamine 6-phosphate + D-lactate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia
- Gene Name:
- guaD
- Uniprot ID:
- P76641
- Molecular weight:
- 50244
Reactions
| Guanine + H(2)O = xanthine + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid
- Gene Name:
- mhpC
- Uniprot ID:
- P77044
- Molecular weight:
- 32585
Reactions
| (2E,4Z)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H(2)O = (2E)-2-hydroxypenta-2,4-dienoate + succinate. |
| (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H(2)O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate. |
- General function:
- Involved in L-rhamnonate dehydratase activity
- Specific function:
- Catalyzes the dehydration of L-rhamnonate to 2-keto-3- deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L- mannonate and D-gulonate, although less efficiently, but not 2- keto-4-hydroxyheptane-1,7-dioate
- Gene Name:
- rhmD
- Uniprot ID:
- P77215
- Molecular weight:
- 44226
Reactions
| L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O. |
- General function:
- Involved in 2-methylcitrate dehydratase activity
- Specific function:
- Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate. Also seems to be responsible for the residual aconitase activity of the acnAB-null strain
- Gene Name:
- prpD
- Uniprot ID:
- P77243
- Molecular weight:
- 53951
Reactions
| (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H(2)O. |
- General function:
- Involved in flavin adenine dinucleotide binding
- Specific function:
- Xanthine + NAD(+) + H(2)O = urate + NADH
- Gene Name:
- yagS
- Uniprot ID:
- P77324
- Molecular weight:
- 33858
Reactions
| Xanthine + NAD(+) + H(2)O = urate + NADH. |
| Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH. |
- General function:
- Involved in dimethyl sulfoxide reductase activity
- Specific function:
- Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds
- Gene Name:
- ynfE
- Uniprot ID:
- P77374
- Molecular weight:
- 89779
- General function:
- Involved in 3-hydroxyacyl-CoA dehydrogenase activity
- Specific function:
- Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long-chain fatty acids
- Gene Name:
- fadJ
- Uniprot ID:
- P77399
- Molecular weight:
- 77072
Reactions
| (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. |
| (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. |
| (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. |
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
- Specific function:
- Involved in the anaerobic utilization of allantoin. Converts allantoate to (S)-ureidoglycolate and ammonia
- Gene Name:
- allC
- Uniprot ID:
- P77425
- Molecular weight:
- 45694
- General function:
- Involved in metabolic process
- Specific function:
- Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo
- Gene Name:
- sufS
- Uniprot ID:
- P77444
- Molecular weight:
- 44433
Reactions
| L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor. |
| L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor. |
- General function:
- Involved in glutaminase activity
- Specific function:
- L-glutamine + H(2)O = L-glutamate + NH(3)
- Gene Name:
- glsA1
- Uniprot ID:
- P77454
- Molecular weight:
- 32903
Reactions
| L-glutamine + H(2)O = L-glutamate + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- Could possibly oxidize fatty acids using specific components
- Gene Name:
- paaG
- Uniprot ID:
- P77467
- Molecular weight:
- 28404
Reactions
| 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Xanthine + NAD(+) + H(2)O = urate + NADH
- Gene Name:
- yagR
- Uniprot ID:
- P77489
- Molecular weight:
- 78088
Reactions
| Xanthine + NAD(+) + H(2)O = urate + NADH. |
| Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH. |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
- Gene Name:
- anmK
- Uniprot ID:
- P77570
- Molecular weight:
- 39496
Reactions
| ATP + 1,6-anhydro-N-acetyl-beta-muramate + H(2)O = ADP + N-acetylmuramate 6-phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid
- Gene Name:
- mhpD
- Uniprot ID:
- P77608
- Molecular weight:
- 28890
Reactions
| 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H(2)O. |
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- Specific function unknown
- Gene Name:
- yahI
- Uniprot ID:
- P77624
- Molecular weight:
- 33931
- General function:
- Involved in allantoinase activity
- Specific function:
- Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
- Gene Name:
- allB
- Uniprot ID:
- P77671
- Molecular weight:
- 49601
Reactions
| (S)-allantoin + H(2)O = allantoate. |
- General function:
- Involved in aminobutyraldehyde dehydrogenase activity
- Specific function:
- Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency
- Gene Name:
- ydcW
- Uniprot ID:
- P77674
- Molecular weight:
- 50830
Reactions
| 4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH. |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Hydrolysis of (1->4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini
- Gene Name:
- yagH
- Uniprot ID:
- P77713
- Molecular weight:
- 60825
Reactions
| Hydrolysis of (1->4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini. |
- General function:
- Involved in ureidoglycolate hydrolase activity
- Specific function:
- Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate
- Gene Name:
- allA
- Uniprot ID:
- P77731
- Molecular weight:
- 18169
Reactions
| (S)-ureidoglycolate + H(2)O = glyoxylate + 2 NH(3) + CO(2). |
- General function:
- Involved in dimethyl sulfoxide reductase activity
- Specific function:
- Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds
- Gene Name:
- ynfF
- Uniprot ID:
- P77783
- Molecular weight:
- 89986
- General function:
- Involved in hydrolase activity
- Specific function:
- Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order
- Gene Name:
- nudG
- Uniprot ID:
- P77788
- Molecular weight:
- 15046
Reactions
| CTP + H(2)O = CMP + diphosphate. |
- General function:
- Involved in FMN reductase activity
- Specific function:
- Catalyzes an NAD(P)H-dependent reduction of FMN, but is also able to reduce FAD or riboflavin
- Gene Name:
- ssuE
- Uniprot ID:
- P80644
- Molecular weight:
- 21253
Reactions
| FMNH(2) + NADP(+) = FMN + NADPH. |
- General function:
- Involved in alkanesulfonate monooxygenase activity
- Specific function:
- Involved in desulfonation of aliphatic sulfonates. Catalyzes the conversion of pentanesulfonic acid to sulfite and pentaldehyde and is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers
- Gene Name:
- ssuD
- Uniprot ID:
- P80645
- Molecular weight:
- 41736
Reactions
| An alkanesufonate (R-CH(2)-SO(3)H) + FMNH(2) + O(2) = an aldehyde (R-CHO) + FMN + sulfite + H(2)O. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde
- Gene Name:
- feaB
- Uniprot ID:
- P80668
- Molecular weight:
- 53699
Reactions
| Phenylacetaldehyde + NAD(+) + H(2)O = phenylacetate + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism). Deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage
- Gene Name:
- xdhA
- Uniprot ID:
- Q46799
- Molecular weight:
- 81320
Reactions
| Xanthine + NAD(+) + H(2)O = urate + NADH. |
| Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH. |
- General function:
- Involved in flavin adenine dinucleotide binding
- Specific function:
- Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism)
- Gene Name:
- xdhB
- Uniprot ID:
- Q46800
- Molecular weight:
- 31557
Reactions
| Xanthine + NAD(+) + H(2)O = urate + NADH. |
| Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Iron-sulfur subunit of the xanthine dehydrogenase complex
- Gene Name:
- xdhC
- Uniprot ID:
- Q46801
- Molecular weight:
- 16922
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- Specific function:
- Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown
- Gene Name:
- hyuA
- Uniprot ID:
- Q46806
- Molecular weight:
- 51025
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- Specific function unknown
- Gene Name:
- yqeA
- Uniprot ID:
- Q46807
- Molecular weight:
- 33071
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate
- Gene Name:
- bglA
- Uniprot ID:
- Q46829
- Molecular weight:
- 55361
Reactions
| 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate. |
- General function:
- Involved in cellular amino acid catabolic process
- Specific function:
- Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is unknown
- Gene Name:
- gudX
- Uniprot ID:
- Q46915
- Molecular weight:
- 48849
- General function:
- Involved in nucleotide binding
- Specific function:
- Involved in copper export. May also be involved in silver export
- Gene Name:
- copA
- Uniprot ID:
- Q59385
- Molecular weight:
- 87872
Reactions
| ATP + H(2)O + Cu(+)(In) = ADP + phosphate + Cu(+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Specific function unknown
- Gene Name:
- ytfR
- Uniprot ID:
- Q6BEX0
- Molecular weight:
- 55259
- General function:
- Involved in galactonate dehydratase activity
- Specific function:
- Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate
- Gene Name:
- dgoD
- Uniprot ID:
- Q6BF17
- Molecular weight:
- 42523
Reactions
| D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O. |
- General function:
- Involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- Specific function:
- Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process
- Gene Name:
- nudF
- Uniprot ID:
- Q93K97
- Molecular weight:
- 23667
Reactions
| ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency
- Gene Name:
- torZ
- Uniprot ID:
- P46923
- Molecular weight:
- 88964
Reactions
| Trimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+). |
- General function:
- Involved in phosphatase activity
- Specific function:
- Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position
- Gene Name:
- gmhB
- Uniprot ID:
- P63228
- Molecular weight:
- 21294
Reactions
| D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(2)O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate. |
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport
- Gene Name:
- artI
- Uniprot ID:
- P30859
- Molecular weight:
- 26929
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Binds L-arginine with high affinity
- Gene Name:
- artJ
- Uniprot ID:
- P30860
- Molecular weight:
- 26829
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- artQ
- Uniprot ID:
- P0AE34
- Molecular weight:
- 26217
- General function:
- Involved in nucleotide binding
- Specific function:
- Has low ATPase activity. The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation
- Gene Name:
- sufC
- Uniprot ID:
- P77499
- Molecular weight:
- 27582
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of the binding-protein-dependent transport system ydcSTUV
- Gene Name:
- ydcS
- Uniprot ID:
- P76108
- Molecular weight:
- 42295
- General function:
- Involved in nucleotide binding
- Specific function:
- Probably part of a binding-protein-dependent transport system ydcSTUV. Probably responsible for energy coupling to the transport system
- Gene Name:
- ydcT
- Uniprot ID:
- P77795
- Molecular weight:
- 37040
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of the binding-protein-dependent transport system ydcSTUV; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ydcU
- Uniprot ID:
- P77156
- Molecular weight:
- 34360
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of the binding-protein-dependent transport system ydcSTUV; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ydcV
- Uniprot ID:
- P0AFR9
- Molecular weight:
- 28722
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- yjfF
- Uniprot ID:
- P37772
- Molecular weight:
- 34977
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Specific function unknown
- Gene Name:
- ytfQ
- Uniprot ID:
- P39325
- Molecular weight:
- 34344
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ytfT
- Uniprot ID:
- P39328
- Molecular weight:
- 35659
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for maltose; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- malF
- Uniprot ID:
- P02916
- Molecular weight:
- 57013
- General function:
- Involved in cobalamin transport
- Specific function:
- Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane
- Gene Name:
- btuC
- Uniprot ID:
- P06609
- Molecular weight:
- 34949
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane
- Gene Name:
- fhuB
- Uniprot ID:
- P06972
- Molecular weight:
- 70422
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- pstA
- Uniprot ID:
- P07654
- Molecular weight:
- 32321
- General function:
- Involved in lipopolysaccharide transport
- Specific function:
- Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane
- Gene Name:
- lptG
- Uniprot ID:
- P0ADC6
- Molecular weight:
- 39618
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for L-arabinose. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- araH
- Uniprot ID:
- P0AE26
- Molecular weight:
- 34211
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- artM
- Uniprot ID:
- P0AE30
- Molecular weight:
- 24914
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- cysW
- Uniprot ID:
- P0AEB0
- Molecular weight:
- 32537
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- dppB
- Uniprot ID:
- P0AEF8
- Molecular weight:
- 37497
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- dppC
- Uniprot ID:
- P0AEG1
- Molecular weight:
- 32308
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- glnP
- Uniprot ID:
- P0AEQ6
- Molecular weight:
- 24364
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- gltJ
- Uniprot ID:
- P0AER3
- Molecular weight:
- 27502
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- gltK
- Uniprot ID:
- P0AER5
- Molecular weight:
- 24914
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- hisM
- Uniprot ID:
- P0AEU3
- Molecular weight:
- 26870
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane
- Gene Name:
- livH
- Uniprot ID:
- P0AEX7
- Molecular weight:
- 32982
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- modB
- Uniprot ID:
- P0AF01
- Molecular weight:
- 24939
- General function:
- Involved in lipopolysaccharide-transporting ATPase acti
- Specific function:
- Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane
- Gene Name:
- lptF
- Uniprot ID:
- P0AF98
- Molecular weight:
- 40357
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
- Gene Name:
- nikC
- Uniprot ID:
- P0AFA9
- Molecular weight:
- 30362
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- oppB
- Uniprot ID:
- P0AFH2
- Molecular weight:
- 33443
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- oppC
- Uniprot ID:
- P0AFH6
- Molecular weight:
- 33022
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine
- Gene Name:
- potB
- Uniprot ID:
- P0AFK4
- Molecular weight:
- 31062
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine
- Gene Name:
- potC
- Uniprot ID:
- P0AFK6
- Molecular weight:
- 29111
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine
- Gene Name:
- potI
- Uniprot ID:
- P0AFL1
- Molecular weight:
- 30540
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- pstC
- Uniprot ID:
- P0AGH8
- Molecular weight:
- 34121
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for ribose. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- rbsC
- Uniprot ID:
- P0AGI1
- Molecular weight:
- 33452
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- xylH
- Uniprot ID:
- P0AGI4
- Molecular weight:
- 41030
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ugpA
- Uniprot ID:
- P10905
- Molecular weight:
- 33264
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ugpE
- Uniprot ID:
- P10906
- Molecular weight:
- 31499
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline
- Gene Name:
- proW
- Uniprot ID:
- P14176
- Molecular weight:
- 37619
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fecD
- Uniprot ID:
- P15029
- Molecular weight:
- 34131
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fecC
- Uniprot ID:
- P15030
- Molecular weight:
- 34892
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- cysU
- Uniprot ID:
- P16701
- Molecular weight:
- 30292
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane
- Gene Name:
- livM
- Uniprot ID:
- P22729
- Molecular weight:
- 46269
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- mglC
- Uniprot ID:
- P23200
- Molecular weight:
- 35550
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fepD
- Uniprot ID:
- P23876
- Molecular weight:
- 33871
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fepG
- Uniprot ID:
- P23877
- Molecular weight:
- 34910
- General function:
- Involved in nucleotide binding
- Specific function:
- Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system
- Gene Name:
- cydC
- Uniprot ID:
- P23886
- Molecular weight:
- 62920
- General function:
- Involved in nucleotide binding
- Specific function:
- Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system
- Gene Name:
- cydD
- Uniprot ID:
- P29018
- Molecular weight:
- 65055
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine
- Gene Name:
- potH
- Uniprot ID:
- P31135
- Molecular weight:
- 35489
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex thiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- thiP
- Uniprot ID:
- P31549
- Molecular weight:
- 59532
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system AlsBAC for D-allose; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- alsC
- Uniprot ID:
- P32720
- Molecular weight:
- 34315
- General function:
- Involved in transporter activity
- Specific function:
- May be part of an ABC transporter complex involved in uptake of osmoprotectant molecules. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- yehW
- Uniprot ID:
- P33359
- Molecular weight:
- 25514
- General function:
- Involved in transporter activity
- Specific function:
- May be part of an ABC transporter complex involved in uptake of osmoprotectant molecules. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- yehY
- Uniprot ID:
- P33361
- Molecular weight:
- 41138
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
- Gene Name:
- nikB
- Uniprot ID:
- P33591
- Molecular weight:
- 35248
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- hisQ
- Uniprot ID:
- P52094
- Molecular weight:
- 24649
- General function:
- Involved in nucleotide binding
- Specific function:
- Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
- Gene Name:
- msbA
- Uniprot ID:
- P60752
- Molecular weight:
- 64460
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for maltose; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- malG
- Uniprot ID:
- P68183
- Molecular weight:
- 32225
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex gsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable)
- Gene Name:
- gsiC
- Uniprot ID:
- P75798
- Molecular weight:
- 34066
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex gsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable)
- Gene Name:
- gsiD
- Uniprot ID:
- P75799
- Molecular weight:
- 33238
- General function:
- Involved in transporter activity
- Specific function:
- Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ssuC
- Uniprot ID:
- P75851
- Molecular weight:
- 28925
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ddpB
- Uniprot ID:
- P77308
- Molecular weight:
- 37345
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ddpC
- Uniprot ID:
- P77463
- Molecular weight:
- 31971
- General function:
- Involved in transporter activity
- Specific function:
- Part of a binding-protein-dependent transport system for taurine. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- tauC
- Uniprot ID:
- Q47539
- Molecular weight:
- 29812
- General function:
- Involved in hydro-lyase activity
- Specific function:
- Involved in saturated fatty acids biosynthesis
- Gene Name:
- fabZ
- Uniprot ID:
- P0A6Q6
- Molecular weight:
- 17033
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably represents the nickel binder
- Gene Name:
- nikA
- Uniprot ID:
- P33590
- Molecular weight:
- 58718
- General function:
- Involved in electron carrier activity
- Specific function:
- Involved in electron transfer (Probable)
- Gene Name:
- napG
- Uniprot ID:
- P0AAL3
- Molecular weight:
- 24924
- General function:
- Involved in transporter activity
- Specific function:
- This protein specifically binds sulfate and is involved in its transmembrane transport
- Gene Name:
- sbp
- Uniprot ID:
- P0AG78
- Molecular weight:
- 36659
- General function:
- Involved in GTP binding
- Specific function:
- GTP-driven Fe(2+) uptake system
- Gene Name:
- feoB
- Uniprot ID:
- P33650
- Molecular weight:
- 84473
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates fructose 1-phosphate and 6-phosphogluconate
- Gene Name:
- yqaB
- Uniprot ID:
- P77475
- Molecular weight:
- 20780
- General function:
- Involved in intramolecular lyase activity
- Specific function:
- Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose. It also catalyzes the conversion between beta-allofuranose and beta-allopyranose
- Gene Name:
- rbsD
- Uniprot ID:
- P04982
- Molecular weight:
- 15292
Reactions
| Beta-D-ribopyranose = beta-D-ribofuranose. |
| Beta-D-allopyranose = beta-D-allofuranose. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (Probable). It has also been shown to be involved in formyl-L-methionine transport
- Gene Name:
- metN
- Uniprot ID:
- P30750
- Molecular weight:
- 37788
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system
- Gene Name:
- ddpD
- Uniprot ID:
- P77268
- Molecular weight:
- 36100
- General function:
- Involved in catalytic activity
- Specific function:
- Specific function unknown
- Gene Name:
- yigL
- Uniprot ID:
- P27848
- Molecular weight:
- 29708
Reactions
| Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate. |
| Sugar phosphate + H(2)O = sugar + phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system
- Gene Name:
- glnQ
- Uniprot ID:
- P10346
- Molecular weight:
- 26731
- General function:
- Involved in sulfur compound metabolic process
- Specific function:
- Part of a binding-protein-dependent transport system for aliphatic sulfonates. Putative binding protein
- Gene Name:
- ssuA
- Uniprot ID:
- P75853
- Molecular weight:
- 34557
- General function:
- Involved in maltose transmembrane transporter activity
- Specific function:
- Involved in the high-affinity maltose membrane transport system malEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides
- Gene Name:
- malE
- Uniprot ID:
- P0AEX9
- Molecular weight:
- 43387
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Specific function unknown
- Gene Name:
- yneI
- Uniprot ID:
- P76149
- Molecular weight:
- 49717
Reactions
| Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H. |
- General function:
- Involved in Mo-molybdopterin cofactor biosynthetic process
- Specific function:
- Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP
- Gene Name:
- moeA
- Uniprot ID:
- P12281
- Molecular weight:
- 44067
Reactions
| Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP. |
- General function:
- Involved in binding
- Specific function:
- Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin
- Gene Name:
- fepB
- Uniprot ID:
- P0AEL6
- Molecular weight:
- 34283
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system
- Gene Name:
- oppF
- Uniprot ID:
- P77737
- Molecular weight:
- 37197
- General function:
- Involved in ATP binding
- Specific function:
- Specific function unknown
- Gene Name:
- ygfA
- Uniprot ID:
- P0AC28
- Molecular weight:
- 21105
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Makes part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source
- Gene Name:
- rutC
- Uniprot ID:
- P0AFQ5
- Molecular weight:
- 13763
- General function:
- Involved in transferase activity, transferring pentosyl groups
- Specific function:
- IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR
- Gene Name:
- hisH
- Uniprot ID:
- P60595
- Molecular weight:
- 21653
Reactions
| 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O. |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose
- Gene Name:
- xylF
- Uniprot ID:
- P37387
- Molecular weight:
- 35734
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
- Gene Name:
- znuC
- Uniprot ID:
- P0A9X1
- Molecular weight:
- 27867
- General function:
- Involved in glycerol metabolic process
- Specific function:
- Specific function unknown
- Gene Name:
- yggF
- Uniprot ID:
- P21437
- Molecular weight:
- 34323
Reactions
| D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP-ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A)
- Gene Name:
- nudE
- Uniprot ID:
- P45799
- Molecular weight:
- 21153
Reactions
| ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate. |
- General function:
- Involved in iron-sulfur cluster assembly
- Specific function:
- The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation
- Gene Name:
- sufB
- Uniprot ID:
- P77522
- Molecular weight:
- 54745
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system
- Gene Name:
- dppD
- Uniprot ID:
- P0AAG0
- Molecular weight:
- 35844
- General function:
- Involved in hydrolase activity
- Specific function:
- Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro, catalyzing the hydrolysis of the thioester bond
- Gene Name:
- ybgC
- Uniprot ID:
- P0A8Z3
- Molecular weight:
- 15562
- General function:
- Involved in hydrolase activity, hydrolyzing N-glycosyl compounds
- Specific function:
- Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively
- Gene Name:
- rihA
- Uniprot ID:
- P41409
- Molecular weight:
- 33823
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Specific function unknown
- Gene Name:
- maoC
- Uniprot ID:
- P77455
- Molecular weight:
- 73002
Reactions
| 2-oxepin-2(3H)-ylideneacetyl-CoA + H(2)O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde. |
| 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP(+) + H(2)O = 3-oxo-5,6-dehydrosuberyl-CoA + NADPH. |
- General function:
- Involved in carboxypeptidase activity
- Specific function:
- Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
- Gene Name:
- dacC
- Uniprot ID:
- P08506
- Molecular weight:
- 43609
Reactions
| Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions. Also shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis- pNPP)
- Gene Name:
- ulaG
- Uniprot ID:
- P39300
- Molecular weight:
- 40060
Reactions
| L-ascorbate 6-phosphate + H(2)O = 3-dehydro-L-gulonate 6-phosphate. |
- General function:
- Involved in electron carrier activity
- Specific function:
- Involved in electron transfer
- Gene Name:
- napH
- Uniprot ID:
- P33934
- Molecular weight:
- 31873
- General function:
- Involved in cytochrome bo3 ubiquinol oxidase activity
- Specific function:
- Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration
- Gene Name:
- cyoA
- Uniprot ID:
- P0ABJ1
- Molecular weight:
- 34911
Reactions
| Ubiquinol-8 + O(2) = Ubiquinone-8 + H(2)O. |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Specific function unknown
- Gene Name:
- cyaY
- Uniprot ID:
- P27838
- Molecular weight:
- 12231
- General function:
- Involved in carboxypeptidase activity
- Specific function:
- Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
- Gene Name:
- dacD
- Uniprot ID:
- P33013
- Molecular weight:
- 43346
Reactions
| Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS
- Gene Name:
- thiF
- Uniprot ID:
- P30138
- Molecular weight:
- 26970
Reactions
| ATP + [ThiS] = diphosphate + adenylyl-[ThiS]. |
- General function:
- Involved in transporter activity
- Specific function:
- Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system
- Gene Name:
- mppA
- Uniprot ID:
- P77348
- Molecular weight:
- 59900
- General function:
- Involved in FMN binding
- Specific function:
- Low-potential electron donor to a number of redox enzymes (Potential)
- Gene Name:
- fldB
- Uniprot ID:
- P0ABY4
- Molecular weight:
- 19700
- General function:
- Involved in catalytic activity
- Specific function:
- Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z
- Gene Name:
- moaA
- Uniprot ID:
- P30745
- Molecular weight:
- 37346
- General function:
- Involved in catalytic activity
- Specific function:
- May hydrolyze mannosyl-D-glycerate to mannose-6- phosphate and glycerate
- Gene Name:
- mngB
- Uniprot ID:
- P54746
- Molecular weight:
- 100014
Reactions
| 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H(2)O = D-mannose 6-phosphate + D-glycerate. |
- General function:
- Involved in iron ion binding
- Specific function:
- Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase torZ. Required for electron transfer to the torZ terminal enzyme
- Gene Name:
- torY
- Uniprot ID:
- P52005
- Molecular weight:
- 40286
- General function:
- Involved in transporter activity
- Specific function:
- This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (hisJ) interact with a common membrane-bound receptor, hisP
- Gene Name:
- argT
- Uniprot ID:
- P09551
- Molecular weight:
- 27991
- General function:
- Involved in binding
- Specific function:
- Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC
- Gene Name:
- btuF
- Uniprot ID:
- P37028
- Molecular weight:
- 29367
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Part of the binding-protein-dependent transport system AlsBAC for D-allose
- Gene Name:
- alsB
- Uniprot ID:
- P39265
- Molecular weight:
- 32910
- General function:
- Involved in FMN binding
- Specific function:
- Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase
- Gene Name:
- fldA
- Uniprot ID:
- P61949
- Molecular weight:
- 19737
- General function:
- Involved in anaerobic electron transport chain
- Specific function:
- Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the dmsAB dimer to the membrane and stabilizes it
- Gene Name:
- dmsC
- Uniprot ID:
- P18777
- Molecular weight:
- 30826
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex gsiABCD involved in glutathione import. Responsible for energy coupling to the transport system
- Gene Name:
- gsiA
- Uniprot ID:
- P75796
- Molecular weight:
- 69113
- General function:
- Involved in RNA binding
- Specific function:
- Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by iscS
- Gene Name:
- thiI
- Uniprot ID:
- P77718
- Molecular weight:
- 54973
Reactions
| L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide. |
| [IscS]-SSH + [ThiS]-COAMP = [IscS]-SH + [ThiS]-COSH + AMP. |
- General function:
- Involved in penicillin binding
- Specific function:
- Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates
- Gene Name:
- mrdA
- Uniprot ID:
- P0AD65
- Molecular weight:
- 70856
- General function:
- Involved in protein complex assembly
- Specific function:
- Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
- Gene Name:
- ccmC
- Uniprot ID:
- P0ABM1
- Molecular weight:
- 27885
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport
- Gene Name:
- cysP
- Uniprot ID:
- P16700
- Molecular weight:
- 37614
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
- Gene Name:
- thiG
- Uniprot ID:
- P30139
- Molecular weight:
- 26896
Reactions
| 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H(2)O. |
- General function:
- Involved in nucleotide binding
- Specific function:
- May be part of an ABC transporter complex involved in uptake of osmoprotectant molecules. Probably responsible for energy coupling to the transport system
- Gene Name:
- yehX
- Uniprot ID:
- P33360
- Molecular weight:
- 34424
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
- Specific function:
- Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable)
- Gene Name:
- arnD
- Uniprot ID:
- P76472
- Molecular weight:
- 33112
Reactions
| 4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H(2)O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate. |
- General function:
- Involved in transporter activity
- Specific function:
- This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity
- Gene Name:
- oppA
- Uniprot ID:
- P23843
- Molecular weight:
- 60899
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system
- Gene Name:
- lptB
- Uniprot ID:
- P0A9V1
- Molecular weight:
- 26800
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system
- Gene Name:
- dppF
- Uniprot ID:
- P37313
- Molecular weight:
- 37560
- General function:
- Involved in catalytic activity
- Specific function:
- Hydrolyzes the alpha-1,6-glucosidic linkages in glycogen which has first been partially depolymerized by phosphorylase. Shows only very little activity with native glycogen
- Gene Name:
- glgX
- Uniprot ID:
- P15067
- Molecular weight:
- 73576
- General function:
- Involved in phosphate ion binding
- Specific function:
- Part of the ABC transporter complex pstSACB involved in phosphate import
- Gene Name:
- pstS
- Uniprot ID:
- P0AG82
- Molecular weight:
- 37024
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation
- Gene Name:
- paaB
- Uniprot ID:
- P76078
- Molecular weight:
- 10942
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate
- Gene Name:
- thiS
- Uniprot ID:
- O32583
- Molecular weight:
- 7311
- General function:
- Not Available
- Specific function:
- Not known; overproduction leads to camphor resistance and chromosome condensation
- Gene Name:
- crcA
- Uniprot ID:
- P37001
- Molecular weight:
- 21770
- General function:
- Not Available
- Specific function:
- Participates in cysteine desulfuration mediated by sufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for sufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of sufS, an intermediate product of cysteine desulfuration process. Together with the sufBCD complex, it thereby enhances up to 50- fold, the cysteine desulfurase activity of sufS. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Does not affect the selenocysteine lyase activity of sufS
- Gene Name:
- sufE
- Uniprot ID:
- P76194
- Molecular weight:
- 15800
- General function:
- Involved in heme transporter activity
- Specific function:
- Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
- Gene Name:
- ccmB
- Uniprot ID:
- P0ABL8
- Molecular weight:
- 23618
- General function:
- Involved in lipopolysaccharide transmembrane transporter activity
- Specific function:
- Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane
- Gene Name:
- lptC
- Uniprot ID:
- P0ADV9
- Molecular weight:
- 21703
- General function:
- Involved in cytochrome o ubiquinol oxidase activity
- Specific function:
- Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration
- Gene Name:
- cyoD
- Uniprot ID:
- P0ABJ6
- Molecular weight:
- 12029
- General function:
- Involved in electron carrier activity
- Specific function:
- Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)
- Gene Name:
- grxD
- Uniprot ID:
- P0AC69
- Molecular weight:
- 12879
- General function:
- Involved in serine-type D-Ala-D-Ala carboxypeptidase activity
- Specific function:
- Cell wall formation. May play a specialized role in remodeling the cell wall. Specifically hydrolyze the DD- diaminopimelate-alanine bonds in high-molecular-mass murein sacculi
- Gene Name:
- pbpG
- Uniprot ID:
- P0AFI5
- Molecular weight:
- 33887
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D-galactose (approximately 2-fold reduction) and D- fucose (approximately 40-fold reduction)
- Gene Name:
- araF
- Uniprot ID:
- P02924
- Molecular weight:
- 35541
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system (Probable)
- Gene Name:
- thiQ
- Uniprot ID:
- P31548
- Molecular weight:
- 24999
- General function:
- Involved in oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- Specific function:
- Part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source
- Gene Name:
- rutA
- Uniprot ID:
- P75898
- Molecular weight:
- 42219
Reactions
| Uracil + FMNH(2) + O(2) = (Z)-3-ureidoacrylate peracid + FMN + H(2)O. |
| Thymine + FMNH(2) + O(2) = (Z)-2-methylureidoacrylate peracid + FMN + H(2)O. |
- General function:
- Involved in catalytic activity
- Specific function:
- IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit
- Gene Name:
- hisF
- Uniprot ID:
- P60664
- Molecular weight:
- 28454
Reactions
| 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O. |
- General function:
- Involved in transport
- Specific function:
- Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (Potential)
- Gene Name:
- ccmD
- Uniprot ID:
- P0ABM5
- Molecular weight:
- 7745
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the radical-mediated cleavage of tyrosine to dehydroglycine and p-cresol
- Gene Name:
- thiH
- Uniprot ID:
- P30140
- Molecular weight:
- 43320
Reactions
| L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H(+). |
- General function:
- Involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- Specific function:
- Catalyzes the hydrolysis of GDP-mannose. Can also use other substrates, catalyzing the hydrolysis of the pyrophosphate bond, releasing a nucleoside monophosphate and a phosphorylated moiety, depending on the substrate
- Gene Name:
- nudK
- Uniprot ID:
- P37128
- Molecular weight:
- 21749
Reactions
| GDP-mannose + H(2)O = GMP + mannose-1-phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system
- Gene Name:
- artP
- Uniprot ID:
- P0AAF6
- Molecular weight:
- 27022
- General function:
- Involved in transporter activity
- Specific function:
- Member of a multicomponent binding-protein-dependent transport system (the proU transporter) which serves as the glycine betaine/L-proline transporter
- Gene Name:
- proX
- Uniprot ID:
- P0AFM2
- Molecular weight:
- 36022
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system
- Gene Name:
- gltL
- Uniprot ID:
- P0AAG3
- Molecular weight:
- 26661
- General function:
- Involved in lipopolysaccharide binding
- Specific function:
- Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain of LPS
- Gene Name:
- lptA
- Uniprot ID:
- P0ADV1
- Molecular weight:
- 20127
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Involved in the high-affinity D-ribose membrane transport system and also serves as the primary chemoreceptor for chemotaxis
- Gene Name:
- rbsB
- Uniprot ID:
- P02925
- Molecular weight:
- 30950
- General function:
- Involved in nucleotide binding
- Specific function:
- Component of the leucine-specific transport system
- Gene Name:
- livG
- Uniprot ID:
- P0A9S7
- Molecular weight:
- 28427
- General function:
- Involved in oxidoreductase activity
- Specific function:
- May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation
- Gene Name:
- paaA
- Uniprot ID:
- P76077
- Molecular weight:
- 35499
Reactions
| Phenylacetyl-CoA + NADPH + O(2) = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP(+) + H(2)O. |
- General function:
- Involved in transporter activity
- Specific function:
- Component of the high-affinity histidine permease, a binding-protein-dependent transport system. The other components are proteins hisQ, hisM, and hisP
- Gene Name:
- hisJ
- Uniprot ID:
- P0AEU0
- Molecular weight:
- 28483
- General function:
- Involved in acyl-CoA hydrolase activity
- Specific function:
- Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known
- Gene Name:
- tesB
- Uniprot ID:
- P0AGG2
- Molecular weight:
- 31966
- General function:
- Involved in protoheme IX farnesyltransferase activity
- Specific function:
- Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
- Gene Name:
- cyoE
- Uniprot ID:
- P0AEA5
- Molecular weight:
- 32248
- General function:
- Involved in oxidation-reduction process
- Specific function:
- Cytochrome oxidase subunit
- Gene Name:
- appB
- Uniprot ID:
- P26458
- Molecular weight:
- 42423
- General function:
- Energy production and conversion
- Specific function:
- A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
- Gene Name:
- atpI
- Uniprot ID:
- P0ABC0
- Molecular weight:
- 13632
- General function:
- Involved in arsenite transmembrane transporter activity
- Specific function:
- Involved in arsenical resistance. Thought to form the channel of an arsenite pump
- Gene Name:
- arsB
- Uniprot ID:
- P0AB93
- Molecular weight:
- 45497
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
- Specific function:
- Makes part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source
- Gene Name:
- rutB
- Uniprot ID:
- P75897
- Molecular weight:
- 25209
Reactions
| (Z)-3-ureidoacrylate peracid + H(2)O = (Z)-3-peroxyaminoacrylate + NH(3). |
| (Z)-3-ureidoacrylate + H(2)O = (Z)-3-aminoacrylate + CO(2) + NH(3). |
| (Z)-2-methyl-ureidoacrylate peracid + H(2)O = (Z)-2-methyl-peroxyaminoacrylate + CO(2) + NH(3). |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions
- Gene Name:
- torA
- Uniprot ID:
- P33225
- Molecular weight:
- 94455
Reactions
| Trimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+). |
- General function:
- Involved in amino acid transport
- Specific function:
- This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids
- Gene Name:
- livJ
- Uniprot ID:
- P0AD96
- Molecular weight:
- 39076
- General function:
- Involved in ATP binding
- Specific function:
- Involved in the high-affinity zinc uptake transport system
- Gene Name:
- znuB
- Uniprot ID:
- P39832
- Molecular weight:
- 27728
- General function:
- Involved in protein-heme linkage
- Specific function:
- Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
- Gene Name:
- ccmE
- Uniprot ID:
- P69490
- Molecular weight:
- 17698
- General function:
- Involved in nucleoside-triphosphatase activity
- Specific function:
- Specific function unknown
- Gene Name:
- yjjX
- Uniprot ID:
- P39411
- Molecular weight:
- 18213
Reactions
| A nucleoside triphosphate + H(2)O = a nucleoside diphosphate + monophosphate. |
- General function:
- Involved in metallocarboxypeptidase activity
- Specific function:
- Specific function unknown
- Gene Name:
- mpaA
- Uniprot ID:
- P0ACV6
- Molecular weight:
- 26558
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
- Gene Name:
- nikD
- Uniprot ID:
- P33593
- Molecular weight:
- 26820
Reactions
| ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone
- Gene Name:
- ubiH
- Uniprot ID:
- P25534
- Molecular weight:
- 42288
- General function:
- Involved in transferase activity, transferring phosphorus-containing groups
- Specific function:
- Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis. Specific for aerobically grown log-phase cells
- Gene Name:
- ubiB
- Uniprot ID:
- P0A6A0
- Molecular weight:
- 63202
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
- Gene Name:
- nrfD
- Uniprot ID:
- P32709
- Molecular weight:
- 35042
- General function:
- Involved in nucleotide binding
- Specific function:
- Component of the leucine-specific transport system
- Gene Name:
- livF
- Uniprot ID:
- P22731
- Molecular weight:
- 26310
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system
- Gene Name:
- ddpF
- Uniprot ID:
- P77622
- Molecular weight:
- 34621
- General function:
- Involved in electron carrier activity
- Specific function:
- The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase
- Gene Name:
- grxC
- Uniprot ID:
- P0AC62
- Molecular weight:
- 9137
- General function:
- Energy production and conversion
- Specific function:
- Cytochrome oxidase subunit
- Gene Name:
- appC
- Uniprot ID:
- P26459
- Molecular weight:
- 57919
- General function:
- Involved in binding
- Specific function:
- Binds citrate-dependent Fe(3+); part of the binding- protein-dependent transport system for uptake of citrate-dependent Fe(3+)
- Gene Name:
- fecB
- Uniprot ID:
- P15028
- Molecular weight:
- 33146
- General function:
- Involved in iron ion binding
- Specific function:
- Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase torA. Acts by transferring electrons from the membranous menaquinones to torA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal domain of torC, then from the N-terminus to the C-terminus, and finally to torA. TorC apocytochrome negatively autoregulates the torCAD operon probably by inhibiting the torS kinase activity
- Gene Name:
- torC
- Uniprot ID:
- P33226
- Molecular weight:
- 43606
- General function:
- Involved in transporter activity
- Specific function:
- Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis
- Gene Name:
- dppA
- Uniprot ID:
- P23847
- Molecular weight:
- 60293
- General function:
- Involved in carboxypeptidase activity
- Specific function:
- Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
- Gene Name:
- dacA
- Uniprot ID:
- P0AEB2
- Molecular weight:
- 44444
Reactions
| Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. |
| A beta-lactam + H(2)O = a substituted beta-amino acid. |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor
- Gene Name:
- mglB
- Uniprot ID:
- P0AEE5
- Molecular weight:
- 35712
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
- Gene Name:
- nikE
- Uniprot ID:
- P33594
- Molecular weight:
- 29721
Reactions
| ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). |
- General function:
- Posttranslational modification, protein turnover, chaperones
- Specific function:
- Probable chaperone. Has ATPase activity. Not stimulated by dnaJ
- Gene Name:
- hscC
- Uniprot ID:
- P77319
- Molecular weight:
- 61986
- General function:
- Involved in electron carrier activity
- Specific function:
- Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
- Gene Name:
- nrfC
- Uniprot ID:
- P0AAK7
- Molecular weight:
- 24567
- General function:
- Not Available
- Specific function:
- Specific function unknown
- Gene Name:
- kdpF
- Uniprot ID:
- P36937
- Molecular weight:
- 3072
- General function:
- Involved in transporter activity
- Specific function:
- sn-glycerol-3-phosphate and glycerophosphoryl diester- binding protein interacts with the binding protein-dependent transport system ugpACE
- Gene Name:
- ugpB
- Uniprot ID:
- P0AG80
- Molecular weight:
- 48448
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
- Gene Name:
- tauB
- Uniprot ID:
- Q47538
- Molecular weight:
- 28297
Reactions
| ATP + H(2)O + taurine(Out) = ADP + phosphate + taurine(In). |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system
- Gene Name:
- metQ
- Uniprot ID:
- P28635
- Molecular weight:
- 29432
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the oxidative demethylation of N-methyl-L- tryptophan. Can also use other N-methyl amino acids, including sarcosine, which, however, is a poor substrate
- Gene Name:
- solA
- Uniprot ID:
- P40874
- Molecular weight:
- 40902
Reactions
| N-methyl-L-tryptophan + H(2)O + O(2) = L-tryptophan + formaldehyde + H(2)O(2). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
- Gene Name:
- modC
- Uniprot ID:
- P09833
- Molecular weight:
- 39102
Reactions
| ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In). |
- General function:
- Involved in transporter activity
- Specific function:
- May be part of an ABC transporter complex involved in uptake of osmoprotectant molecules
- Gene Name:
- osmF
- Uniprot ID:
- P33362
- Molecular weight:
- 32609
- General function:
- Involved in thiamine biosynthetic process
- Specific function:
- Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
- Gene Name:
- thiC
- Uniprot ID:
- P30136
- Molecular weight:
- 70850
Reactions
| 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO. |
- General function:
- Involved in argininosuccinate synthase activity
- Specific function:
- Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
- Gene Name:
- queC
- Uniprot ID:
- P77756
- Molecular weight:
- 25514
Reactions
| 7-carboxy-7-carbaguanine + NH(3) + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H(2)O. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system
- Gene Name:
- oppD
- Uniprot ID:
- P76027
- Molecular weight:
- 37188
- General function:
- Involved in Mo-molybdopterin cofactor biosynthetic process
- Specific function:
- Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z
- Gene Name:
- moaC
- Uniprot ID:
- P0A738
- Molecular weight:
- 17467
- General function:
- Involved in metal ion binding
- Specific function:
- Involved in the high-affinity zinc uptake transport system
- Gene Name:
- znuA
- Uniprot ID:
- P39172
- Molecular weight:
- 33777
- General function:
- Not Available
- Specific function:
- May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation
- Gene Name:
- paaD
- Uniprot ID:
- P76080
- Molecular weight:
- 18324
- General function:
- Involved in oxidation-reduction process
- Specific function:
- Cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration
- Gene Name:
- cydB
- Uniprot ID:
- P0ABK2
- Molecular weight:
- 42453
Reactions
| Ubiquinol-8 + O(2) = Ubiquinone-8 + H(2)O. |
- General function:
- Involved in heme binding
- Specific function:
- Plays a role in nitrite reduction
- Gene Name:
- nrfB
- Uniprot ID:
- P0ABL1
- Molecular weight:
- 20714
- General function:
- Involved in oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
- Specific function:
- Aldose sugar dehydrogenase with broad substrate specificity. The physiological substrate is unknown. Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L- arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network
- Gene Name:
- yliI
- Uniprot ID:
- P75804
- Molecular weight:
- 41054
- General function:
- Involved in oxidation-reduction process
- Specific function:
- One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase
- Gene Name:
- norW
- Uniprot ID:
- P37596
- Molecular weight:
- 41403
Reactions
| Reduced NO reductase rubredoxin + NAD(+) = oxidized NO reductase rubredoxin + NADH. |
- General function:
- Involved in iron-sulfur cluster assembly
- Specific function:
- The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the fhuF protein
- Gene Name:
- sufD
- Uniprot ID:
- P77689
- Molecular weight:
- 46822
- General function:
- Energy production and conversion
- Specific function:
- Small subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme napC protein, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism
- Gene Name:
- napB
- Uniprot ID:
- P0ABL3
- Molecular weight:
- 16297
- General function:
- Involved in cytochrome-c oxidase activity
- Specific function:
- Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer
- Gene Name:
- cyoB
- Uniprot ID:
- P0ABI8
- Molecular weight:
- 74367
Reactions
| Ubiquinol-8 + O(2) = Ubiquinone-8 + H(2)O. |
- General function:
- Amino acid transport and metabolism
- Specific function:
- Part of the binding-protein-dependent transport system for putrescine. Probably responsible for energy coupling to the transport system
- Gene Name:
- potG
- Uniprot ID:
- P31134
- Molecular weight:
- 41930
- General function:
- Involved in 3-(3-hydroxyphenyl)propionate hydroxylase activity
- Specific function:
- Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI)
- Gene Name:
- mhpA
- Uniprot ID:
- P77397
- Molecular weight:
- 62185
Reactions
| 3-(3-hydroxyphenyl)propanoate + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+). |
| (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O(2) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(2)O + NAD(+). |
- General function:
- Involved in protein binding
- Specific function:
- Involved in reducing some disulfides in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase
- Gene Name:
- grxB
- Uniprot ID:
- P0AC59
- Molecular weight:
- 24350
- General function:
- Involved in metallopeptidase activity
- Specific function:
- Hydrolyzes D-Ala-D-Ala. May have a role in cell-wall turnover
- Gene Name:
- ddpX
- Uniprot ID:
- P77790
- Molecular weight:
- 21213
Reactions
| D-Ala-D-Ala + H(2)O = 2 D-Ala. |
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex gsiABCD involved in glutathione import
- Gene Name:
- gsiB
- Uniprot ID:
- P75797
- Molecular weight:
- 56470
- General function:
- Involved in N-acetylmuramoyl-L-alanine amidase activity
- Specific function:
- Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety
- Gene Name:
- ampD
- Uniprot ID:
- P13016
- Molecular weight:
- 20536
Reactions
| Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. |
- General function:
- Involved in anaerobic electron transport chain
- Specific function:
- Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. The C subunit anchors the other two subunits to the membrane and stabilize the catalytic subunits
- Gene Name:
- ynfH
- Uniprot ID:
- P76173
- Molecular weight:
- 30523
- General function:
- Involved in transporter activity
- Specific function:
- Part of a binding-protein-dependent transport system for taurine
- Gene Name:
- tauA
- Uniprot ID:
- Q47537
- Molecular weight:
- 34266
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable)
- Gene Name:
- ssuB
- Uniprot ID:
- P0AAI1
- Molecular weight:
- 27738
- General function:
- Involved in electron carrier activity
- Specific function:
- The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase
- Gene Name:
- grxA
- Uniprot ID:
- P68688
- Molecular weight:
- 9685
- General function:
- Involved in electron carrier activity
- Specific function:
- Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions
- Gene Name:
- trxA
- Uniprot ID:
- P0AA25
- Molecular weight:
- 11807
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate
- Gene Name:
- gltI
- Uniprot ID:
- P37902
- Molecular weight:
- 33420
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
- Specific function:
- Makes part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source
- Gene Name:
- rutD
- Uniprot ID:
- P75895
- Molecular weight:
- 28898
Reactions
| (Z)-3-aminoacrylate + H(2)O = malonate semialdehyde + NH(3). |
- General function:
- Involved in amino acid transport
- Specific function:
- This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in E.coli
- Gene Name:
- livK
- Uniprot ID:
- P04816
- Molecular weight:
- 39378
- General function:
- Involved in oxidoreductase activity
- Specific function:
- May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation
- Gene Name:
- paaC
- Uniprot ID:
- P76079
- Molecular weight:
- 27877
- General function:
- Energy production and conversion
- Specific function:
- Cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration
- Gene Name:
- cydA
- Uniprot ID:
- P0ABJ9
- Molecular weight:
- 58205
Reactions
| Ubiquinol-8 + O(2) = Ubiquinone-8 + H(2)O. |
- General function:
- Involved in serine-type carboxypeptidase activity
- Specific function:
- Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction
- Gene Name:
- dacB
- Uniprot ID:
- P24228
- Molecular weight:
- 51798
Reactions
| Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
- Gene Name:
- pdxH
- Uniprot ID:
- P0AFI7
- Molecular weight:
- 25545
Reactions
| Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2). |
| Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2). |
- General function:
- Replication, recombination and repair
- Specific function:
- Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate
- Gene Name:
- mutT
- Uniprot ID:
- P08337
- Molecular weight:
- 14927
Reactions
| 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate. |
- General function:
- Involved in iron ion binding
- Specific function:
- Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the reductase at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase
- Gene Name:
- norV
- Uniprot ID:
- Q46877
- Molecular weight:
- 54234
- General function:
- Involved in heme binding
- Specific function:
- Mediates electron flow from quinones to the napAB complex
- Gene Name:
- napC
- Uniprot ID:
- P0ABL5
- Molecular weight:
- 23100
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a glutamine-transport system glnHPQ
- Gene Name:
- glnH
- Uniprot ID:
- P0AEQ3
- Molecular weight:
- 27190
- General function:
- Involved in heme-copper terminal oxidase activity
- Specific function:
- Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration
- Gene Name:
- cyoC
- Uniprot ID:
- P0ABJ3
- Molecular weight:
- 22623
Reactions
| Ubiquinol-8 + O(2) = Ubiquinone-8 + H(2)O. |
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine. Polyamine binding protein
- Gene Name:
- potF
- Uniprot ID:
- P31133
- Molecular weight:
- 40839
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport
- Gene Name:
- ddpA
- Uniprot ID:
- P76128
- Molecular weight:
- 57641
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein
- Gene Name:
- potD
- Uniprot ID:
- P0AFK9
- Molecular weight:
- 38867
- General function:
- Involved in binding
- Specific function:
- Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin
- Gene Name:
- fhuD
- Uniprot ID:
- P07822
- Molecular weight:
- 32998
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex thiBPQ involved in thiamine import
- Gene Name:
- thiB
- Uniprot ID:
- P31550
- Molecular weight:
- 36163
- General function:
- Involved in unfolded protein binding
- Specific function:
- Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 1. Required for the insertion of the molybdenum into the apo-NarG subunit, maybe by keeping NarG in an appropriate competent-open conformation for the molybdenum cofactor insertion to occur. NarJ maintains the apoNarGH complex in a soluble state. Upon insertion of the molybdenum cofactor, NarJ seems to dissociate from the activated soluble NarGH complex, before its association with the NarI subunit on the membrane
- Gene Name:
- narJ
- Uniprot ID:
- P0AF26
- Molecular weight:
- 26449
- General function:
- Involved in molybdate transmembrane-transporting ATPase activity
- Specific function:
- Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity
- Gene Name:
- modA
- Uniprot ID:
- P37329
- Molecular weight:
- 27364
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- ftnA
- Uniprot ID:
- P0A998
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- yniC
- Uniprot ID:
- P77247
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- yfbT
- Uniprot ID:
- P77625
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- yjdM
- Uniprot ID:
- P0AFJ1
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- cobB
- Uniprot ID:
- P75960
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- ebgC
- Uniprot ID:
- P0AC73
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- paoA
- Uniprot ID:
- P77165
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- yfcG
- Uniprot ID:
- P77526
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- yeaW
- Uniprot ID:
- P0ABR7
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- aes
- Uniprot ID:
- P23872
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- ylbA
- Uniprot ID:
- P75713
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- nrfE
- Uniprot ID:
- P32710
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- hiuH
- Uniprot ID:
- P76341
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- nfsA
- Uniprot ID:
- P17117
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- nemA
- Uniprot ID:
- P77258
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- tilS
- Uniprot ID:
- P52097
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- paaI
- Uniprot ID:
- P76084
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It uses temperature-induced exposure of structured hydrophobic domains to capture and stabilizes early unfolding and denatured protein intermediates under severe thermal stress. Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. It can also use phenylglyoxal as substrate. Glyoxalase activity protects cells against dicarbonyl stress. Displays an aminopeptidase activity that is specific against peptide substrates with alanine or basic amino acids (lysine, arginine) at N-terminus. Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It uses temperature-induced exposure of structured hydrophobic domains to capture and stabilizes early unfolding and denatured protein intermediates under severe thermal stress. Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. It can also use phenylglyoxal as substrate. Glyoxalase activity protects cells against dicarbonyl stress. Displays an aminopeptidase activity that is specific against peptide substrates with alanine or basic amino acids (lysine, arginine) at N-terminus.
- Gene Name:
- hchA
- Uniprot ID:
- P31658
- Molecular weight:
- Not Available
Reactions
| (R)-lactate = methylglyoxal + H(2)O. |
| (R)-lactate = methylglyoxal + H(2)O. |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- May perform analogous functions in iron detoxification and storage to that of animal ferritins
- Gene Name:
- bfr
- Uniprot ID:
- P0ABD3
- Molecular weight:
- 18495
Reactions
| 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O. |
- General function:
- Replication, recombination and repair
- Specific function:
- Has a helix-destabilizing activity, which is not coupled to the ATPase activity. Can unwind the 23S rRNA as well as 16S rRNA. Exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA. Could play a major role in ribosome assembly, specifically in the assembly process of the active center of 50S ribosomal subunits
- Gene Name:
- dbpA
- Uniprot ID:
- P21693
- Molecular weight:
- 49187
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- Acts in 50S ribosomal subunit biogenesis at low temperatures, acting after srmB. Has a helix-destabilizing activity; however it is unclear whether it requires ATP:according to PubMed:8552679, it does not require ATP, while according to PubMed:15196029 and PubMed:15554978, it requires ATP. Requires a helicase substrate with a single-stranded overhang. Plays a key role in optimal cell growth at low temperature and is required for normal cell division. When overexpressed suppresses cold-sensitive mutants of the rpsB gene (ribosomal protein S2) and of the smbA2 cold-sensitive mutant (pyrH, uridylate kinase). Can replace rhlB, another ATP-dependent RNA helicase, in the RNA degradosome in vitro. Stimulates translation, probably at the level of initiation, of some mRNAs
- Gene Name:
- deaD
- Uniprot ID:
- P0A9P6
- Molecular weight:
- 70546
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Transcription
- Specific function:
- Probable helicase involved in DNA repair and perhaps also replication
- Gene Name:
- dinG
- Uniprot ID:
- P27296
- Molecular weight:
- 81439
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with dnaC protein, primase, and other prepriming proteins
- Gene Name:
- dnaB
- Uniprot ID:
- P0ACB0
- Molecular weight:
- 52390
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Signal transduction mechanisms
- Specific function:
- Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
- Gene Name:
- gmr
- Uniprot ID:
- P77334
- Molecular weight:
- 74664
Reactions
| Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine. |
- General function:
- Replication, recombination and repair
- Specific function:
- Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP
- Gene Name:
- helD
- Uniprot ID:
- P15038
- Molecular weight:
- 77976
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- Not yet known
- Gene Name:
- hrpA
- Uniprot ID:
- P43329
- Molecular weight:
- 149027
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- ATP + H(2)O = ADP + phosphate
- Gene Name:
- hrpB
- Uniprot ID:
- P37024
- Molecular weight:
- 89147
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system
- Gene Name:
- phnC
- Uniprot ID:
- P16677
- Molecular weight:
- 29430
Reactions
| ATP + H(2)O + phosphonate(Out) = ADP + phosphate + phosphonate(In). |
- General function:
- Replication, recombination and repair
- Specific function:
- Critical role in recombination and DNA repair. Help process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3' to 5' polarity. recG unwind branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (csdR) and R-loop formation
- Gene Name:
- recG
- Uniprot ID:
- P24230
- Molecular weight:
- 76430
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase
- Gene Name:
- recQ
- Uniprot ID:
- P15043
- Molecular weight:
- 68363
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
- Gene Name:
- rep
- Uniprot ID:
- P09980
- Molecular weight:
- 77024
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- Can carry out ATP-dependent unwinding of double stranded RNA. Has a role in RNA decay. Involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation
- Gene Name:
- rhlB
- Uniprot ID:
- P0A8J8
- Molecular weight:
- 47125
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- Acts as an ATP-dependent RNA helicase, able to unwind ds-RNA
- Gene Name:
- rhlE
- Uniprot ID:
- P25888
- Molecular weight:
- 49989
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- May have a phosphotransferase activity
- Gene Name:
- yjgF
- Uniprot ID:
- P0AF93
- Molecular weight:
- 13612
Reactions
| Iminobutyrate + H(2)O = 2-oxobutanoate + NH(3). |
- General function:
- Replication, recombination and repair
- Specific function:
- The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of ruvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA
- Gene Name:
- ruvA
- Uniprot ID:
- P0A809
- Molecular weight:
- 22086
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing
- Gene Name:
- ruvB
- Uniprot ID:
- P0A812
- Molecular weight:
- 37173
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Replication, recombination and repair
- Specific function:
- RNA-dependent ATPase activity. Acts in 50S ribosomal subunit biogenesis at low temperatures, acting before deaD/csdA. Suppressor of a mutant defective in 50S ribosomal subunit assembly. Probably interacts with 23S ribosomal RNA
- Gene Name:
- srmB
- Uniprot ID:
- P21507
- Molecular weight:
- 49914
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Energy production and conversion
- Specific function:
- Deaminates adenosine-34 to inosine in tRNA-Arg2. Mutation in this protein makes E.coli resistant to the toxic proteins encoded by the gef gene family. Essential for cell viability
- Gene Name:
- tadA
- Uniprot ID:
- P68398
- Molecular weight:
- 18717
Reactions
| Adenosine + H(2)O = inosine + NH(3). |
- General function:
- Replication, recombination and repair
- Specific function:
- Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair
- Gene Name:
- uvrD
- Uniprot ID:
- P03018
- Molecular weight:
- 81989
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- ATP + H(2)O = ADP + phosphate
- Gene Name:
- yoaA
- Uniprot ID:
- P76257
- Molecular weight:
- 70377
Reactions
| ATP + H(2)O = ADP + phosphate. |
- General function:
- oxidative phosphorylation
- Specific function:
- Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap.
- Gene Name:
- cydX
- Uniprot ID:
- P56100
- Molecular weight:
- 4041
- General function:
- riboflavin biosynthetic process
- Specific function:
- Catalyzes the dephosphorylation of 5-amino-6-(5-phospho-D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway (PubMed:24123841). Is also able to dephosphorylate flavin mononucleotide (FMN) and other phosphoric acid esters (PubMed:16990279) (PubMed:24123841). YigB is important for the formation of dormant persister cells (PubMed:18519731).
- Gene Name:
- yigB
- Uniprot ID:
- P0ADP0
- Molecular weight:
- 27121
Reactions
| 5-amino-6-(5-phospho-D-ribitylamino)uracil + H(2)O = 5-amino-6-(D-ribitylamino)uracil + phosphate |
- General function:
- cellular amino acid catabolic process
- Specific function:
- Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation.
- Gene Name:
- rspA
- Uniprot ID:
- P38104
- Molecular weight:
- 45968
Reactions
| = |
- General function:
- polysaccharide catabolic process
- Specific function:
- ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF. It can also use chitobiose and chitotriose as substrates.
- Gene Name:
- chbG
- Uniprot ID:
- P37794
- Molecular weight:
- 27773
Reactions
| 2-(acetylamino)-4-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + H(2)O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate |
- General function:
- phospholipid catabolic process
- Specific function:
- Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).
- Gene Name:
- pgpC
- Uniprot ID:
- P0AD42
- Molecular weight:
- 24439
Reactions
| Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate |
- General function:
- pyridine nucleotide biosynthetic process
- Specific function:
- Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates.
- Gene Name:
- pncC
- Uniprot ID:
- P0A6G3
- Molecular weight:
- 17581
Reactions
| Beta-nicotinamide D-ribonucleotide + H(2)O = beta-nicotinate D-ribonucleotide + NH(3) |
- General function:
- threonylcarbamoyladenosine biosynthetic process
- Specific function:
- Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles.
- Gene Name:
- tsaC
- Uniprot ID:
- P45748
- Molecular weight:
- 20767
Reactions
| L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O |
- General function:
- organic phosphonate catabolic process
- Specific function:
- Catalyzes the hydrolysis of the cyclic ribose-phosphate to form alpha-D-ribose 1,5-bisphosphate.
- Gene Name:
- phnP
- Uniprot ID:
- P16692
- Molecular weight:
- 27847
Reactions
| 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H(2)O = alpha-D-ribose 1,5-bisphosphate |
- General function:
- organic phosphonate catabolic process
- Specific function:
- Catalyzes the hydrolysis of alpha-D-ribose 1-methylphosphonate triphosphate (RPnTP) to form alpha-D-ribose 1-methylphosphonate phosphate (PRPn) and diphosphate.
- Gene Name:
- phnM
- Uniprot ID:
- P16689
- Molecular weight:
- 42010
Reactions
| Alpha-D-ribose 1-methylphosphonate 5-triphosphate + H(2)O = alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate |
- General function:
- carbohydrate metabolic process
- Specific function:
- Not Available
- Gene Name:
- lacZ
- Uniprot ID:
- G0ZKW2
- Molecular weight:
- 116482
Reactions
| = |
Transporters
- General function:
- Involved in potassium-transporting ATPase activity
- Specific function:
- One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
- Gene Name:
- kdpA
- Uniprot ID:
- P03959
- Molecular weight:
- 59189
Reactions
| ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
- Gene Name:
- kdpB
- Uniprot ID:
- P03960
- Molecular weight:
- 72198
Reactions
| ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In). |
- General function:
- Involved in potassium-transporting ATPase activity
- Specific function:
- One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
- Gene Name:
- kdpC
- Uniprot ID:
- P03961
- Molecular weight:
- 20267
Reactions
| ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In). |
- General function:
- Involved in proteolysis
- Specific function:
- Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation
- Gene Name:
- pepN
- Uniprot ID:
- P04825
- Molecular weight:
- 98918
Reactions
| Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system
- Gene Name:
- rbsA
- Uniprot ID:
- P04983
- Molecular weight:
- 55041
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
- Gene Name:
- btuD
- Uniprot ID:
- P06611
- Molecular weight:
- 27081
Reactions
| ATP + H(2)O + vitamin B12(Out) = ADP + phosphate + vitamin B12(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system
- Gene Name:
- hisP
- Uniprot ID:
- P07109
- Molecular weight:
- 28653
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system
- Gene Name:
- fhuC
- Uniprot ID:
- P07821
- Molecular weight:
- 28886
Reactions
| ATP + H(2)O + iron chelate(Out) = ADP + phosphate + iron chelate(In). |
- General function:
- Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism
- Specific function:
- Produces ATP from ADP in the presence of a proton gradient across the membrane
- Gene Name:
- atpC
- Uniprot ID:
- P0A6E6
- Molecular weight:
- 15068
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable)
- Gene Name:
- araG
- Uniprot ID:
- P0AAF3
- Molecular weight:
- 55018
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable)
- Gene Name:
- mglA
- Uniprot ID:
- P0AAG8
- Molecular weight:
- 56415
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system
- Gene Name:
- pstB
- Uniprot ID:
- P0AAH0
- Molecular weight:
- 29027
Reactions
| ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In). |
- General function:
- Involved in hydrogen ion transmembrane transporter activity
- Specific function:
- Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane
- Gene Name:
- atpB
- Uniprot ID:
- P0AB98
- Molecular weight:
- 30303
- General function:
- Involved in hydrogen ion transmembrane transporter activity
- Specific function:
- Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
- Gene Name:
- atpF
- Uniprot ID:
- P0ABA0
- Molecular weight:
- 17264
- General function:
- Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism
- Specific function:
- This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction
- Gene Name:
- atpH
- Uniprot ID:
- P0ABA4
- Molecular weight:
- 19332
- General function:
- Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism
- Specific function:
- Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
- Gene Name:
- atpG
- Uniprot ID:
- P0ABA6
- Molecular weight:
- 31577
- General function:
- Involved in ATP binding
- Specific function:
- Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
- Gene Name:
- atpA
- Uniprot ID:
- P0ABB0
- Molecular weight:
- 55222
Reactions
| ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
- Gene Name:
- atpD
- Uniprot ID:
- P0ABB4
- Molecular weight:
- 50325
Reactions
| ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters
- Gene Name:
- ugpC
- Uniprot ID:
- P10907
- Molecular weight:
- 39524
Reactions
| ATP + H(2)O + glycerol-3-phosphate(Out) = ADP + phosphate + glycerol-3-phosphate(In). |
- General function:
- Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
- Specific function:
- Bifunctional enzyme with lysozyme/chitinase activity
- Gene Name:
- chiA
- Uniprot ID:
- P13656
- Molecular weight:
- 97057
Reactions
| Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. |
| Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system
- Gene Name:
- fecE
- Uniprot ID:
- P15031
- Molecular weight:
- 28191
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system
- Gene Name:
- cysA
- Uniprot ID:
- P16676
- Molecular weight:
- 41059
Reactions
| ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In). |
- General function:
- Involved in 3-hydroxyacyl-CoA dehydrogenase activity
- Specific function:
- Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities. Involved in the aerobic and anaerobic degradation of long-chain fatty acids
- Gene Name:
- fadB
- Uniprot ID:
- P21177
- Molecular weight:
- 79593
Reactions
| (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. |
| (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. |
| (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. |
| (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system
- Gene Name:
- fepC
- Uniprot ID:
- P23878
- Molecular weight:
- 29784
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- metI
- Uniprot ID:
- P31547
- Molecular weight:
- 23256
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system
- Gene Name:
- alsA
- Uniprot ID:
- P32721
- Molecular weight:
- 56744
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system
- Gene Name:
- fbpC
- Uniprot ID:
- P37009
- Molecular weight:
- 39059
Reactions
| ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose
- Gene Name:
- xylG
- Uniprot ID:
- P37388
- Molecular weight:
- 56470
Reactions
| ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system
- Gene Name:
- malK
- Uniprot ID:
- P68187
- Molecular weight:
- 40990
Reactions
| ATP + H(2)O + maltose(Out) = ADP + phosphate + maltose(In). |
- General function:
- Involved in hydrogen ion transmembrane transporter activity
- Specific function:
- Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of 10 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits
- Gene Name:
- atpE
- Uniprot ID:
- P68699
- Molecular weight:
- 8256
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system
- Gene Name:
- potA
- Uniprot ID:
- P69874
- Molecular weight:
- 43028
Reactions
| ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Specific function unknown
- Gene Name:
- ytfR
- Uniprot ID:
- Q6BEX0
- Molecular weight:
- 55259
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport
- Gene Name:
- artI
- Uniprot ID:
- P30859
- Molecular weight:
- 26929
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Binds L-arginine with high affinity
- Gene Name:
- artJ
- Uniprot ID:
- P30860
- Molecular weight:
- 26829
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- artM
- Uniprot ID:
- P0AE32
- Molecular weight:
- 24914
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- artQ
- Uniprot ID:
- P0AE34
- Molecular weight:
- 26217
- General function:
- Involved in nucleotide binding
- Specific function:
- Has low ATPase activity. The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation
- Gene Name:
- sufC
- Uniprot ID:
- P77499
- Molecular weight:
- 27582
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of the binding-protein-dependent transport system ydcSTUV
- Gene Name:
- ydcS
- Uniprot ID:
- P76108
- Molecular weight:
- 42295
- General function:
- Involved in nucleotide binding
- Specific function:
- Probably part of a binding-protein-dependent transport system ydcSTUV. Probably responsible for energy coupling to the transport system
- Gene Name:
- ydcT
- Uniprot ID:
- P77795
- Molecular weight:
- 37040
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of the binding-protein-dependent transport system ydcSTUV; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ydcU
- Uniprot ID:
- P77156
- Molecular weight:
- 34360
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of the binding-protein-dependent transport system ydcSTUV; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ydcV
- Uniprot ID:
- P0AFR9
- Molecular weight:
- 28722
- General function:
- Involved in nucleotide binding
- Specific function:
- Probably part of a binding-protein-dependent transport system yecCS for an amino acid. Probably responsible for energy coupling to the transport system
- Gene Name:
- yecC
- Uniprot ID:
- P37774
- Molecular weight:
- 27677
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of the binding-protein-dependent transport system yecCS for an amino acid; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- yecS
- Uniprot ID:
- P0AFT2
- Molecular weight:
- 24801
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- yjfF
- Uniprot ID:
- P37772
- Molecular weight:
- 34977
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Specific function unknown
- Gene Name:
- ytfQ
- Uniprot ID:
- P39325
- Molecular weight:
- 34344
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ytfT
- Uniprot ID:
- P39328
- Molecular weight:
- 35659
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex lsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- lsrC
- Uniprot ID:
- B1XEA2
- Molecular weight:
- 36394
- General function:
- Involved in cobalamin transport
- Specific function:
- Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane
- Gene Name:
- btuC
- Uniprot ID:
- B1XG18
- Molecular weight:
- 34949
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for maltose; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- malF
- Uniprot ID:
- P02916
- Molecular weight:
- 57013
- General function:
- Involved in cobalamin transport
- Specific function:
- Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane
- Gene Name:
- btuC
- Uniprot ID:
- P06609
- Molecular weight:
- 34949
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane
- Gene Name:
- fhuB
- Uniprot ID:
- P06972
- Molecular weight:
- 70422
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- pstA
- Uniprot ID:
- P07654
- Molecular weight:
- 32321
- General function:
- Involved in lipopolysaccharide transport
- Specific function:
- Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane
- Gene Name:
- lptG
- Uniprot ID:
- P0ADC6
- Molecular weight:
- 39618
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for L-arabinose. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- araH
- Uniprot ID:
- P0AE26
- Molecular weight:
- 34211
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- artM
- Uniprot ID:
- P0AE30
- Molecular weight:
- 24914
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- cysW
- Uniprot ID:
- P0AEB0
- Molecular weight:
- 32537
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- dppB
- Uniprot ID:
- P0AEF8
- Molecular weight:
- 37497
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- dppC
- Uniprot ID:
- P0AEG1
- Molecular weight:
- 32308
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- glnP
- Uniprot ID:
- P0AEQ6
- Molecular weight:
- 24364
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- gltJ
- Uniprot ID:
- P0AER3
- Molecular weight:
- 27502
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- gltK
- Uniprot ID:
- P0AER5
- Molecular weight:
- 24914
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- hisM
- Uniprot ID:
- P0AEU3
- Molecular weight:
- 26870
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane
- Gene Name:
- livH
- Uniprot ID:
- P0AEX7
- Molecular weight:
- 32982
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- modB
- Uniprot ID:
- P0AF01
- Molecular weight:
- 24939
- General function:
- Involved in lipopolysaccharide-transporting ATPase acti
- Specific function:
- Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane
- Gene Name:
- lptF
- Uniprot ID:
- P0AF98
- Molecular weight:
- 40357
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
- Gene Name:
- nikC
- Uniprot ID:
- P0AFA9
- Molecular weight:
- 30362
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- oppB
- Uniprot ID:
- P0AFH2
- Molecular weight:
- 33443
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- oppC
- Uniprot ID:
- P0AFH6
- Molecular weight:
- 33022
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine
- Gene Name:
- potB
- Uniprot ID:
- P0AFK4
- Molecular weight:
- 31062
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine
- Gene Name:
- potC
- Uniprot ID:
- P0AFK6
- Molecular weight:
- 29111
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine
- Gene Name:
- potI
- Uniprot ID:
- P0AFL1
- Molecular weight:
- 30540
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex lsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable)
- Gene Name:
- lsrD
- Uniprot ID:
- P0AFS1
- Molecular weight:
- 34456
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- pstC
- Uniprot ID:
- P0AGH8
- Molecular weight:
- 34121
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for ribose. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- rbsC
- Uniprot ID:
- P0AGI1
- Molecular weight:
- 33452
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- xylH
- Uniprot ID:
- P0AGI4
- Molecular weight:
- 41030
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ugpA
- Uniprot ID:
- P10905
- Molecular weight:
- 33264
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ugpE
- Uniprot ID:
- P10906
- Molecular weight:
- 31499
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline
- Gene Name:
- proW
- Uniprot ID:
- P14176
- Molecular weight:
- 37619
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fecD
- Uniprot ID:
- P15029
- Molecular weight:
- 34131
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fecC
- Uniprot ID:
- P15030
- Molecular weight:
- 34892
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for phosphonates; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- phnE
- Uniprot ID:
- P16683
- Molecular weight:
- 28383
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- cysU
- Uniprot ID:
- P16701
- Molecular weight:
- 30292
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane
- Gene Name:
- livM
- Uniprot ID:
- P22729
- Molecular weight:
- 46269
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- mglC
- Uniprot ID:
- P23200
- Molecular weight:
- 35550
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fepD
- Uniprot ID:
- P23876
- Molecular weight:
- 33871
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fepG
- Uniprot ID:
- P23877
- Molecular weight:
- 34910
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine
- Gene Name:
- potH
- Uniprot ID:
- P31135
- Molecular weight:
- 35489
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex thiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- thiP
- Uniprot ID:
- P31549
- Molecular weight:
- 59532
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system AlsBAC for D-allose; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- alsC
- Uniprot ID:
- P32720
- Molecular weight:
- 34315
- General function:
- Involved in transporter activity
- Specific function:
- May be part of an ABC transporter complex involved in uptake of osmoprotectant molecules. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- yehW
- Uniprot ID:
- P33359
- Molecular weight:
- 25514
- General function:
- Involved in transporter activity
- Specific function:
- May be part of an ABC transporter complex involved in uptake of osmoprotectant molecules. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- yehY
- Uniprot ID:
- P33361
- Molecular weight:
- 41138
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
- Gene Name:
- nikB
- Uniprot ID:
- P33591
- Molecular weight:
- 35248
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- hisQ
- Uniprot ID:
- P52094
- Molecular weight:
- 24649
- General function:
- Involved in nucleotide binding
- Specific function:
- Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
- Gene Name:
- msbA
- Uniprot ID:
- P60752
- Molecular weight:
- 64460
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for maltose; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- malG
- Uniprot ID:
- P68183
- Molecular weight:
- 32225
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex gsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable)
- Gene Name:
- gsiC
- Uniprot ID:
- P75798
- Molecular weight:
- 34066
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex gsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable)
- Gene Name:
- gsiD
- Uniprot ID:
- P75799
- Molecular weight:
- 33238
- General function:
- Involved in transporter activity
- Specific function:
- Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ssuC
- Uniprot ID:
- P75851
- Molecular weight:
- 28925
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ddpB
- Uniprot ID:
- P77308
- Molecular weight:
- 37345
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- ddpC
- Uniprot ID:
- P77463
- Molecular weight:
- 31971
- General function:
- Involved in transporter activity
- Specific function:
- Part of a binding-protein-dependent transport system for taurine. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- tauC
- Uniprot ID:
- Q47539
- Molecular weight:
- 29812
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably represents the nickel binder
- Gene Name:
- nikA
- Uniprot ID:
- P33590
- Molecular weight:
- 58718
- General function:
- Involved in transporter activity
- Specific function:
- This protein specifically binds sulfate and is involved in its transmembrane transport
- Gene Name:
- sbp
- Uniprot ID:
- P0AG78
- Molecular weight:
- 36659
- General function:
- Involved in GTP binding
- Specific function:
- GTP-driven Fe(2+) uptake system
- Gene Name:
- feoB
- Uniprot ID:
- P33650
- Molecular weight:
- 84473
- General function:
- Involved in porin activity
- Specific function:
- Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the ompL channel is unknown
- Gene Name:
- ompL
- Uniprot ID:
- P76773
- Molecular weight:
- 27200
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (Probable). It has also been shown to be involved in formyl-L-methionine transport
- Gene Name:
- metN
- Uniprot ID:
- P30750
- Molecular weight:
- 37788
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system
- Gene Name:
- ddpD
- Uniprot ID:
- P77268
- Molecular weight:
- 36100
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system
- Gene Name:
- glnQ
- Uniprot ID:
- P10346
- Molecular weight:
- 26731
- General function:
- Involved in sulfur compound metabolic process
- Specific function:
- Part of a binding-protein-dependent transport system for aliphatic sulfonates. Putative binding protein
- Gene Name:
- ssuA
- Uniprot ID:
- P75853
- Molecular weight:
- 34557
- General function:
- Involved in maltose transmembrane transporter activity
- Specific function:
- Involved in the high-affinity maltose membrane transport system malEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides
- Gene Name:
- malE
- Uniprot ID:
- P0AEX9
- Molecular weight:
- 43387
- General function:
- Involved in binding
- Specific function:
- Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin
- Gene Name:
- fepB
- Uniprot ID:
- P0AEL6
- Molecular weight:
- 34283
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system
- Gene Name:
- oppF
- Uniprot ID:
- P77737
- Molecular weight:
- 37197
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose
- Gene Name:
- xylF
- Uniprot ID:
- P37387
- Molecular weight:
- 35734
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
- Gene Name:
- znuC
- Uniprot ID:
- P0A9X1
- Molecular weight:
- 27867
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system
- Gene Name:
- dppD
- Uniprot ID:
- P0AAG0
- Molecular weight:
- 35844
- General function:
- Involved in porin activity
- Specific function:
- May act as a regulator of the RCS-phosphorelay signal transduction pathway
- Gene Name:
- ompG
- Uniprot ID:
- P76045
- Molecular weight:
- 34913
- General function:
- Involved in transporter activity
- Specific function:
- Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system
- Gene Name:
- mppA
- Uniprot ID:
- P77348
- Molecular weight:
- 59900
- General function:
- Involved in transporter activity
- Specific function:
- This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (hisJ) interact with a common membrane-bound receptor, hisP
- Gene Name:
- argT
- Uniprot ID:
- P09551
- Molecular weight:
- 27991
- General function:
- Involved in binding
- Specific function:
- Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC
- Gene Name:
- btuF
- Uniprot ID:
- P37028
- Molecular weight:
- 29367
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Part of the binding-protein-dependent transport system AlsBAC for D-allose
- Gene Name:
- alsB
- Uniprot ID:
- P39265
- Molecular weight:
- 32910
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex gsiABCD involved in glutathione import. Responsible for energy coupling to the transport system
- Gene Name:
- gsiA
- Uniprot ID:
- P75796
- Molecular weight:
- 69113
- General function:
- Involved in transporter activity
- Specific function:
- Non-specific porin
- Gene Name:
- ompN
- Uniprot ID:
- P77747
- Molecular weight:
- 41220
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport
- Gene Name:
- cysP
- Uniprot ID:
- P16700
- Molecular weight:
- 37614
- General function:
- Involved in nucleotide binding
- Specific function:
- May be part of an ABC transporter complex involved in uptake of osmoprotectant molecules. Probably responsible for energy coupling to the transport system
- Gene Name:
- yehX
- Uniprot ID:
- P33360
- Molecular weight:
- 34424
- General function:
- Involved in transporter activity
- Specific function:
- This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity
- Gene Name:
- oppA
- Uniprot ID:
- P23843
- Molecular weight:
- 60899
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system
- Gene Name:
- dppF
- Uniprot ID:
- P37313
- Molecular weight:
- 37560
- General function:
- Involved in phosphate ion binding
- Specific function:
- Part of the ABC transporter complex pstSACB involved in phosphate import
- Gene Name:
- pstS
- Uniprot ID:
- P0AG82
- Molecular weight:
- 37024
- General function:
- Involved in transporter activity
- Specific function:
- Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
- Gene Name:
- phoE
- Uniprot ID:
- P02932
- Molecular weight:
- 38922
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D-galactose (approximately 2-fold reduction) and D- fucose (approximately 40-fold reduction)
- Gene Name:
- araF
- Uniprot ID:
- P02924
- Molecular weight:
- 35541
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system (Probable)
- Gene Name:
- thiQ
- Uniprot ID:
- P31548
- Molecular weight:
- 24999
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system
- Gene Name:
- artP
- Uniprot ID:
- P0AAF6
- Molecular weight:
- 27022
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system
- Gene Name:
- gltL
- Uniprot ID:
- P0AAG3
- Molecular weight:
- 26661
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Involved in the high-affinity D-ribose membrane transport system and also serves as the primary chemoreceptor for chemotaxis
- Gene Name:
- rbsB
- Uniprot ID:
- P02925
- Molecular weight:
- 30950
- General function:
- Involved in nucleotide binding
- Specific function:
- Component of the leucine-specific transport system
- Gene Name:
- livG
- Uniprot ID:
- P0A9S7
- Molecular weight:
- 28427
- General function:
- Involved in transporter activity
- Specific function:
- Component of the high-affinity histidine permease, a binding-protein-dependent transport system. The other components are proteins hisQ, hisM, and hisP
- Gene Name:
- hisJ
- Uniprot ID:
- P0AEU0
- Molecular weight:
- 28483
- General function:
- Involved in amino acid transport
- Specific function:
- This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids
- Gene Name:
- livJ
- Uniprot ID:
- P0AD96
- Molecular weight:
- 39076
- General function:
- Involved in ATP binding
- Specific function:
- Involved in the high-affinity zinc uptake transport system
- Gene Name:
- znuB
- Uniprot ID:
- P39832
- Molecular weight:
- 27728
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
- Gene Name:
- nikD
- Uniprot ID:
- P33593
- Molecular weight:
- 26820
Reactions
| ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Component of the leucine-specific transport system
- Gene Name:
- livF
- Uniprot ID:
- P22731
- Molecular weight:
- 26310
- General function:
- Involved in transporter activity
- Specific function:
- Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity
- Gene Name:
- aqpZ
- Uniprot ID:
- P60844
- Molecular weight:
- 23703
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system
- Gene Name:
- ddpF
- Uniprot ID:
- P77622
- Molecular weight:
- 34621
- General function:
- Involved in binding
- Specific function:
- Binds citrate-dependent Fe(3+); part of the binding- protein-dependent transport system for uptake of citrate-dependent Fe(3+)
- Gene Name:
- fecB
- Uniprot ID:
- P15028
- Molecular weight:
- 33146
- General function:
- Involved in transporter activity
- Specific function:
- Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis
- Gene Name:
- dppA
- Uniprot ID:
- P23847
- Molecular weight:
- 60293
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor
- Gene Name:
- mglB
- Uniprot ID:
- P0AEE5
- Molecular weight:
- 35712
- General function:
- Involved in transporter activity
- Specific function:
- OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
- Gene Name:
- ompF
- Uniprot ID:
- P02931
- Molecular weight:
- 39333
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
- Gene Name:
- nikE
- Uniprot ID:
- P33594
- Molecular weight:
- 29721
Reactions
| ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). |
- General function:
- Not Available
- Specific function:
- Specific function unknown
- Gene Name:
- kdpF
- Uniprot ID:
- P36937
- Molecular weight:
- 3072
- General function:
- Involved in transporter activity
- Specific function:
- sn-glycerol-3-phosphate and glycerophosphoryl diester- binding protein interacts with the binding protein-dependent transport system ugpACE
- Gene Name:
- ugpB
- Uniprot ID:
- P0AG80
- Molecular weight:
- 48448
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
- Gene Name:
- tauB
- Uniprot ID:
- Q47538
- Molecular weight:
- 28297
Reactions
| ATP + H(2)O + taurine(Out) = ADP + phosphate + taurine(In). |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system
- Gene Name:
- metQ
- Uniprot ID:
- P28635
- Molecular weight:
- 29432
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
- Gene Name:
- modC
- Uniprot ID:
- P09833
- Molecular weight:
- 39102
Reactions
| ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In). |
- General function:
- Involved in transporter activity
- Specific function:
- May be part of an ABC transporter complex involved in uptake of osmoprotectant molecules
- Gene Name:
- osmF
- Uniprot ID:
- P33362
- Molecular weight:
- 32609
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system
- Gene Name:
- oppD
- Uniprot ID:
- P76027
- Molecular weight:
- 37188
- General function:
- Involved in metal ion binding
- Specific function:
- Involved in the high-affinity zinc uptake transport system
- Gene Name:
- znuA
- Uniprot ID:
- P39172
- Molecular weight:
- 33777
- General function:
- Amino acid transport and metabolism
- Specific function:
- Part of the binding-protein-dependent transport system for putrescine. Probably responsible for energy coupling to the transport system
- Gene Name:
- potG
- Uniprot ID:
- P31134
- Molecular weight:
- 41930
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex gsiABCD involved in glutathione import
- Gene Name:
- gsiB
- Uniprot ID:
- P75797
- Molecular weight:
- 56470
- General function:
- Involved in transporter activity
- Specific function:
- Part of a binding-protein-dependent transport system for taurine
- Gene Name:
- tauA
- Uniprot ID:
- Q47537
- Molecular weight:
- 34266
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable)
- Gene Name:
- ssuB
- Uniprot ID:
- P0AAI1
- Molecular weight:
- 27738
- General function:
- Involved in transporter activity
- Specific function:
- Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
- Gene Name:
- ompC
- Uniprot ID:
- P06996
- Molecular weight:
- 40368
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate
- Gene Name:
- gltI
- Uniprot ID:
- P37902
- Molecular weight:
- 33420
- General function:
- Involved in amino acid transport
- Specific function:
- This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in E.coli
- Gene Name:
- livK
- Uniprot ID:
- P04816
- Molecular weight:
- 39378
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a glutamine-transport system glnHPQ
- Gene Name:
- glnH
- Uniprot ID:
- P0AEQ3
- Molecular weight:
- 27190
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine. Polyamine binding protein
- Gene Name:
- potF
- Uniprot ID:
- P31133
- Molecular weight:
- 40839
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex ddpABCDF, which is probably involved in D,D-dipeptide transport
- Gene Name:
- ddpA
- Uniprot ID:
- P76128
- Molecular weight:
- 57641
- General function:
- Involved in transporter activity
- Specific function:
- Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein
- Gene Name:
- potD
- Uniprot ID:
- P0AFK9
- Molecular weight:
- 38867
- General function:
- Involved in structural molecule activity
- Specific function:
- Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes
- Gene Name:
- ompA
- Uniprot ID:
- P0A910
- Molecular weight:
- 37201
- General function:
- Involved in binding
- Specific function:
- Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin
- Gene Name:
- fhuD
- Uniprot ID:
- P07822
- Molecular weight:
- 32998
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex thiBPQ involved in thiamine import
- Gene Name:
- thiB
- Uniprot ID:
- P31550
- Molecular weight:
- 36163
- General function:
- Involved in molybdate transmembrane-transporting ATPase activity
- Specific function:
- Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity
- Gene Name:
- modA
- Uniprot ID:
- P37329
- Molecular weight:
- 27364
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system
- Gene Name:
- phnC
- Uniprot ID:
- P16677
- Molecular weight:
- 29430
Reactions
| ATP + H(2)O + phosphonate(Out) = ADP + phosphate + phosphonate(In). |
- General function:
- ATPase activity, coupled to transmembrane movement of substances
- Specific function:
- Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth.
- Gene Name:
- lsrA
- Uniprot ID:
- P77257
- Molecular weight:
- 55820
- General function:
- periplasmic space
- Specific function:
- Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable).
- Gene Name:
- lsrB
- Uniprot ID:
- P76142
- Molecular weight:
- 36684
- General function:
- transporter activity
- Specific function:
- Part of a binding-protein-dependent transport system for cystine.
- Gene Name:
- fliY
- Uniprot ID:
- P0AEM9
- Molecular weight:
- 29038
- General function:
- alkylphosphonate transport
- Specific function:
- Phosphonate binding protein that is part of the phosphonate uptake system. Exhibits high affinity for 2-aminoethylphosphonate, and somewhat less affinity to ethylphosphonate, methylphosphonate, phosphonoacetate and phenylphosphonate.
- Gene Name:
- phnD
- Uniprot ID:
- P16682
- Molecular weight:
- 37370