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Record Information
Version	2.0
Creation Date	2015-09-08 17:50:04 -0600
Update Date	2015-09-16 14:50:11 -0600
Secondary Accession Numbers	ECMDB24207
Identification
Name:	α-D-glucose 6-phosphate
Description	Glucose 6 phosphate (alpha-D-glucose 6 phosphate or G6P) is the alpha-anomer of glucose-6-phosphate. There are two anomers of glucose 6 phosphate, the alpha anomer and the beta anomer. Glucose 6 phosphate is an ester of glucose with phosphoric acid. Glucose-6-phosphate is a phosphorylated glucose molecule on carbon 6. G6P can travel down two metabolic pathways, glycolysis and the pentose phosphate pathway. It costs the cell 1 ATP to store the 1 glucose molecule and virtually no energy to remove it from storage. It is important to note that glucose-6-phosphate is an allosteric activator of glycogen synthase. On the other hand, glycogen synthase is inhibited when it is phosphorylated by protein kinase during times of high stress. -- Wikipedia.
Structure	MOLSDFPDBSMILESInChI × Structure for #<Compound:0xac9e6bf8> Close
Synonyms:	α-D-glucose 6-phosphoric acid
Chemical Formula:	C6H11O9P
Weight:	Average: 258.12 Monoisotopic: 258.015166092
InChI Key:	NBSCHQHZLSJFNQ-UHFFFAOYSA-L
InChI:	InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/p-2
CAS number:	Not Available
IUPAC Name:	(3,4,5,6-tetrahydroxyoxan-2-yl)methyl phosphate
Traditional IUPAC Name:	(3,4,5,6-tetrahydroxyoxan-2-yl)methyl phosphate
SMILES:	OC1OC(COP([O-])([O-])=O)C(O)C(O)C1O
Chemical Taxonomy
Description	belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups.
Kingdom	Organic compounds
Super Class	Organic oxygen compounds
Class	Organooxygen compounds
Sub Class	Carbohydrates and carbohydrate conjugates
Direct Parent	Hexose phosphates
Alternative Parents	Monosaccharide phosphates Oxanes Alkyl phosphates Secondary alcohols Hemiacetals Polyols Oxacyclic compounds Organic oxides Hydrocarbon derivatives Organic anions
Substituents	Hexose phosphate Monosaccharide phosphate Organic phosphoric acid derivative Oxane Alkyl phosphate Phosphoric acid ester Hemiacetal Secondary alcohol Oxacycle Organoheterocyclic compound Polyol Alcohol Hydrocarbon derivative Organic oxide Organic anion Aliphatic heteromonocyclic compound
Molecular Framework	Aliphatic heteromonocyclic compounds
External Descriptors	a hexose-6-phosphate (MANNOSE-6P )
Physical Properties
State:	Not Available
Charge:	-2
Melting point:	Not Available
Experimental Properties:	Property Value Source
Predicted Properties	Property Value Source Water Solubility 95 g/L ALOGPS logP -2.3 ALOGPS logP -3.1 ChemAxon logS -0.49 ALOGPS pKa (Strongest Acidic) 1.22 ChemAxon pKa (Strongest Basic) -3.6 ChemAxon Physiological Charge -2 ChemAxon Hydrogen Acceptor Count 8 ChemAxon Hydrogen Donor Count 4 ChemAxon Polar Surface Area 162.57 Ų ChemAxon Rotatable Bond Count 3 ChemAxon Refractivity 44.55 m³·mol⁻¹ ChemAxon Polarizability 20.49 ų ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule Yes ChemAxon
Biological Properties
Cellular Locations:	Cytoplasm
Reactions:	α-D-glucose 6-phosphate + Mannose 6-phosphate > α-D-glucose 1-phosphate α-D-glucose 6-phosphate + Mannose 6-phosphate > Alpha-D-glucose 1-phosphate alpha-D-Glucose + HPr - phosphorylated > α-D-glucose 6-phosphate + HPr + Mannose 6-phosphate
SMPDB Pathways:	Amino sugar and nucleotide sugar metabolism II PW000887 Amino sugar and nucleotide sugar metabolism III PW000895 Galactose metabolism PW000821 galactose degradation/Leloir Pathway PW000884
KEGG Pathways:	Galactose metabolism ec00052
EcoCyc Pathways:	Not Available
Concentrations
	Not Available
Spectra
Spectra:	Spectrum Type Description Splash Key Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 10V, Positive splash10-0a4i-0490000000-b3fd53bffdb24df0bbcd View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 20V, Positive splash10-03dj-1960000000-24e14c556590d92e8b0e View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 40V, Positive splash10-0f6t-4900000000-3caf4b8bee63aa687ad2 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 10V, Negative splash10-0a4i-0090000000-35229ddd3efd37a1990b View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 20V, Negative splash10-0a4i-6290000000-2d01316127ba65ccdb37 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 40V, Negative splash10-053v-9200000000-7296d89ab58a8e9511fd View in MoNA 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer
References
References:	Not Available
Synthesis Reference:	Not Available
Material Safety Data Sheet (MSDS)	Not Available
Links
External Links:	Resource Link CHEBI ID Not Available HMDB ID HMDB0304534 Pubchem Compound ID 4459709 Kegg ID Not Available ChemSpider ID 3658466 Wikipedia ID Not Available BioCyc ID Not Available