| Record Information |
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| Version | 2.0 |
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| Creation Date | 2012-10-24 09:55:05 -0600 |
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| Update Date | 2015-12-09 12:08:27 -0700 |
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| Secondary Accession Numbers | |
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| Identification |
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| Name: | PG(19:0cycv8c/12:0(3-OH)) |
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| Description | PG(19:0cycv8c/12:0(3-OH)) is a phosphatidylglycerol. Phosphatidylglycerols consist of a glycerol 3-phosphate backbone esterified to either saturated or unsaturated fatty acids on carbons 1 and 2. As is the case with diacylglycerols, phosphatidylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PG(19:0cycv8c/12:0(3-OH)), in particular, consists of one heptadec-11-12-cyclo-anoyl chain to the C-1 atom, and one 3-hydroxydodecanoyl to the C-2 atom. In E. coli glycerophospholipid metabolism, phosphatidylglycerol is formed from phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by a sequence of enzymatic reactions that proceeds via two intermediates, cytidine diphosphate diacylglycerol (CDP-diacylglycerol) and phosphatidylglycerophosphate (PGP, a phosphorylated phosphatidylglycerol). Phosphatidylglycerols, along with CDP-diacylglycerol, also serve as precursor molecules for the synthesis of cardiolipin, a phospholipid found in membranes. |
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| Structure | |
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| Synonyms: | - 1-(heptadec-11-12-cyclo-anoyl)-2-3-hydroxydodecanoyl-sn-glycero-3-phospho-(1'-glycerol)
- 1-(heptadec-11-12-cyclo-anoyl)-2-3-hydroxydodecanoyl-sn-glycero-3-phosphoglycerol
- 1-(heptadec-11-12-cyclo-anoyl)-2-3-hydroxydodecanoyl-sn-glycero-3-phosphoglycerol
- 1-heptadec-11-12-cyclo-anoyl-2-3-hydroxydodecanoyl-sn-glycero-3-phospho-(1'-glycerol)
- 1-heptadec-11-12-cyclo-anoyl-2-3-hydroxydodecanoyl-sn-glycero-3-phosphoglycerol
- GPG(19:0/12:0)
- GPG(31:0)
- PG(19:0/12:0)
- PG(31:0)
- Phosphatidylglycerol(19:0/12:0)
- Phosphatidylglycerol(31:0)
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| Chemical Formula: | C37H71O11P |
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| Weight: | Average: 722.938
Monoisotopic: 722.473400104 |
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| InChI Key: | DBCURBSBXHHYJY-BISNVOBLSA-N |
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| InChI: | InChI=1S/C37H71O11P/c1-3-5-7-9-11-15-19-23-33(39)26-37(42)45-29-35(30-47-49(43,44)46-28-34(40)27-38)48-36(41)24-20-16-13-10-12-14-18-22-32-25-31(32)21-17-8-6-4-2/h31-35,38-40H,3-30H2,1-2H3,(H,43,44)/t31?,32?,33?,34-,35+/m0/s1 |
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| CAS number: | Not Available |
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| IUPAC Name: | [(2S)-2,3-dihydroxypropoxy][(2R)-2-{[10-(2-hexylcyclopropyl)decanoyl]oxy}-3-[(3-hydroxydodecanoyl)oxy]propoxy]phosphinic acid |
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| Traditional IUPAC Name: | (2S)-2,3-dihydroxypropoxy((2R)-2-{[10-(2-hexylcyclopropyl)decanoyl]oxy}-3-[(3-hydroxydodecanoyl)oxy]propoxy)phosphinic acid |
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| SMILES: | [H][C@](O)(CO)COP(O)(=O)OC[C@@]([H])(COC(=O)CC(O)CCCCCCCCC)OC(=O)CCCCCCCCCC1CC1CCCCCC |
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| Chemical Taxonomy |
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| Description | belongs to the class of organic compounds known as phosphatidylglycerols. These are glycerophosphoglycerols in which two fatty acids are bonded to the 1-glycerol moiety through ester linkages. |
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| Kingdom | Organic compounds |
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| Super Class | Lipids and lipid-like molecules |
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| Class | Glycerophospholipids |
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| Sub Class | Glycerophosphoglycerols |
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| Direct Parent | Phosphatidylglycerols |
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| Alternative Parents | |
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| Substituents | - 1,2-diacylglycerophosphoglycerol
- Beta-hydroxy acid
- Dialkyl phosphate
- Fatty acid ester
- Fatty acyl
- Alkyl phosphate
- Dicarboxylic acid or derivatives
- Phosphoric acid ester
- Organic phosphoric acid derivative
- Hydroxy acid
- 1,2-diol
- Carboxylic acid ester
- Secondary alcohol
- Carboxylic acid derivative
- Primary alcohol
- Hydrocarbon derivative
- Organic oxygen compound
- Carbonyl group
- Organic oxide
- Alcohol
- Organooxygen compound
- Aliphatic homomonocyclic compound
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| Molecular Framework | Aliphatic homomonocyclic compounds |
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| External Descriptors | Not Available |
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| Physical Properties |
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| State: | Solid |
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| Charge: | -1 |
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| Melting point: | Not Available |
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| Experimental Properties: | |
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| Predicted Properties | |
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| Biological Properties |
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| Cellular Locations: | Membrane |
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| Reactions: | |
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| SMPDB Pathways: | | phospholipid biosynthesis (CL(19:0cycv8c/12:0(3-OH)/12:0/12:0)) | PW001992 |    | | phospholipid biosynthesis (CL(19:0cycv8c/12:0(3-OH)/19:0cycv8c/12:0(3-OH))) | PW001993 |    |
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| KEGG Pathways: | - Glycerophospholipid metabolism ec00564
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| EcoCyc Pathways: | Not Available |
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| Concentrations |
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| Not Available |
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| Spectra |
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| Spectra: | |
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| References |
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| References: | - Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
- Taylor SS, Heath EC. (1969) "The incorporation of beta-hydroxy fatty acids into a phospholipid of Escherichia coli B." J Biol Chem. 244(24):6605-16. Pubmed: 4902888
- Yurtsever D. (2007). Fatty acid methyl ester profiling of Enterococcus and Esherichia coli for microbial source tracking. M.sc. Thesis. Villanova University: U.S.A
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| Synthesis Reference: | Not Available |
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| Material Safety Data Sheet (MSDS) | Not Available |
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| Links |
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| External Links: | | Resource | Link |
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| CHEBI ID | Not Available | | HMDB ID | Not Available | | Pubchem Compound ID | Not Available | | Kegg ID | Not Available | | ChemSpider ID | Not Available | | Wikipedia ID | Not Available | | BioCyc ID | Not Available |
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