General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system

Gene Name:

fhuC

Uniprot ID:

P07821

Molecular weight:

28886

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane

Gene Name:

fhuB

Uniprot ID:

P06972

Molecular weight:

70422

General function:

Involved in receptor activity

Specific function:

This receptor binds the ferrichrome-iron ligand. It interacts with the tonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin

Gene Name:

fhuA

Uniprot ID:

P06971

Molecular weight:

82182

General function:

Involved in protein transporter activity

Specific function:

Involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates. Protects exbD from proteolytic degradation and functionally stabilizes tonB

Gene Name:

exbB

Uniprot ID:

P0ABU7

Molecular weight:

26287

General function:

Involved in transporter activity

Specific function:

Involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates

Gene Name:

exbD

Uniprot ID:

P0ABV2

Molecular weight:

15527

General function:

Involved in iron ion transmembrane transporter activity

Specific function:

Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of tonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy- dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins

Gene Name:

tonB

Uniprot ID:

P02929

Molecular weight:

26094

General function:

Involved in binding

Specific function:

Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin

Gene Name:

fhuD

Uniprot ID:

P07822

Molecular weight:

32998