General function:

Lipid transport and metabolism

Specific function:

2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate

Gene Name:

pldB

Uniprot ID:

P07000

Molecular weight:

38978

Reactions

General function:

Involved in phospholipase activity

Specific function:

Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Strong expression leads to outer membrane breakdown and cell death; is dormant in normal growing cells. Required for efficient secretion of bacteriocins

Gene Name:

pldA

Uniprot ID:

P0A921

Molecular weight:

33163

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes phosphatidylglycerophosphate, phosphatidic acid, and lysophosphatidic acid; the pattern of activities varies according to subcellular location

Gene Name:

pgpB

Uniprot ID:

P0A924

Molecular weight:

29021

Reactions

General function:

Involved in phosphatidylglycerophosphatase activity

Specific function:

One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate

Gene Name:

pgpA

Uniprot ID:

P18200

Molecular weight:

19418

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1

Gene Name:

aas

Uniprot ID:

P31119

Molecular weight:

80699

Reactions

General function:

Involved in nucleotide binding

Specific function:

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation

Gene Name:

msbA

Uniprot ID:

P60752

Molecular weight:

64460

General function:

Involved in lipid binding

Specific function:

Interacts with the peptidoglycan both covalently and noncovalently. This interaction contributes to the maintenance of the structural and functional integrity of the cell envelope

Gene Name:

lpp

Uniprot ID:

P69776

Molecular weight:

8323

General function:

Not Available

Specific function:

Not known; overproduction leads to camphor resistance and chromosome condensation

Gene Name:

crcA

Uniprot ID:

P37001

Molecular weight:

21770

General function:

Involved in phosphotransferase activity, for other substituted phosphate groups

Specific function:

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Affects resistance to the gyrase inhibitor novobiocin

Gene Name:

cls

Uniprot ID:

P0A6H8

Molecular weight:

54822

Reactions

General function:

Involved in N-acyltransferase activity

Specific function:

Transfers the fatty acyl group on membrane lipoproteins

Gene Name:

lnt

Uniprot ID:

P23930

Molecular weight:

57065

General function:

Involved in catalytic activity

Specific function:

Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate. Catalyzes little, if any, cardiolipin synthesis in vivo, even when the expression level is very high

Gene Name:

ybhO

Uniprot ID:

P0AA84

Molecular weight:

47633

Reactions

General function:

cardiolipin biosynthetic process

Specific function:

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).

Gene Name:

clsC

Uniprot ID:

P75919

Molecular weight:

53665

Reactions

General function:

phospholipid catabolic process

Specific function:

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

Gene Name:

pgpC

Uniprot ID:

P0AD42

Molecular weight:

24439

Reactions