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Record Information
Version	2.0
Creation Date	2015-06-04 15:16:17 -0600
Update Date	2015-07-23 12:07:06 -0600
Secondary Accession Numbers	ECMDB23782
Identification
Name:	L-Glutamyl-tRNA(Glu)
Description
Structure	MOLSDFPDBSMILESInChI × Structure for #<Compound:0xae8e78b8> Close
Synonyms:	(2S,4R)-2-amino-4-Hydroxypentanedioate (2S,4R)-2-amino-4-Hydroxypentanedioic acid L-erythro-4-Hydroxyglutamate L-erythro-4-Hydroxyglutamic acid
Chemical Formula:	C5H9NO5
Weight:	Average: 163.1287 Monoisotopic: 163.048072403
InChI Key:	HBDWQSHEVMSFGY-STHAYSLISA-N
InChI:	InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
CAS number:	Not Available
IUPAC Name:	(2S,4R)-2-amino-4-hydroxypentanedioic acid
Traditional IUPAC Name:	(2S,4R)-2-amino-4-hydroxypentanedioic acid
SMILES:	N[C@@H](C[C@@H](O)C(O)=O)C(O)=O
Chemical Taxonomy
Description	belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
Kingdom	Organic compounds
Super Class	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Sub Class	Amino acids, peptides, and analogues
Direct Parent	Glutamic acid and derivatives
Alternative Parents	L-alpha-amino acids Short-chain hydroxy acids and derivatives Hydroxy fatty acids Amino fatty acids Dicarboxylic acids and derivatives Alpha hydroxy acids and derivatives 1,3-aminoalcohols Secondary alcohols Amino acids Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
Substituents	Glutamic acid or derivatives Alpha-amino acid L-alpha-amino acid Amino fatty acid Short-chain hydroxy acid Hydroxy fatty acid Alpha-hydroxy acid Fatty acyl Fatty acid Dicarboxylic acid or derivatives Hydroxy acid 1,3-aminoalcohol Amino acid Secondary alcohol Carboxylic acid Organic nitrogen compound Primary aliphatic amine Organonitrogen compound Organooxygen compound Primary amine Hydrocarbon derivative Carbonyl group Organic oxide Amine Organopnictogen compound Organic oxygen compound Alcohol Aliphatic acyclic compound
Molecular Framework	Aliphatic acyclic compounds
External Descriptors	4-hydroxy-L-glutamic acid (CHEBI:21285 )
Physical Properties
State:	Not Available
Charge:	-1
Melting point:	Not Available
Experimental Properties:	Property Value Source
Predicted Properties	Property Value Source Water Solubility 74.3 g/L ALOGPS logP -3.7 ALOGPS logP -4.2 ChemAxon logS -0.34 ALOGPS pKa (Strongest Acidic) 1.68 ChemAxon pKa (Strongest Basic) 9.16 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 6 ChemAxon Hydrogen Donor Count 4 ChemAxon Polar Surface Area 120.85 Ų ChemAxon Rotatable Bond Count 4 ChemAxon Refractivity 32.74 m³·mol⁻¹ ChemAxon Polarizability 14.01 ų ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule Yes ChemAxon
Biological Properties
Cellular Locations:	Cytoplasm
Reactions:	L-Glutamyl-tRNA(Glu) + NADPH + Hydrogen ion + tRNA(Glu) <> (S)-4-Amino-5-oxopentanoate + tRNA(Glu) + NADP + L-Glutamyl-tRNA(Glu) tRNA(Glu) + L-Glutamate + Adenosine triphosphate + tRNA(Glu) <> L-Glutamyl-tRNA(Glu) + Pyrophosphate + Adenosine monophosphate + L-Glutamyl-tRNA(Glu) tRNA(Glu) + L-Glutamate + Adenosine triphosphate <> L-Glutamyl-tRNA(Glu) + Pyrophosphate + Adenosine monophosphate L-Glutamyl-tRNA(Glu) + NADPH + Hydrogen ion + tRNA(Glu) <> (S)-4-Amino-5-oxopentanoate + NADP
SMPDB Pathways:	Not Available
KEGG Pathways:	Aminoacyl-tRNA biosynthesis ec00970 Metabolic pathways eco01100 Porphyrin and chlorophyll metabolism ec00860
EcoCyc Pathways:	Not Available
Concentrations
	Not Available
Spectra
Spectra:	Spectrum Type Description Splash Key Predicted GC-MS Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive splash10-00dl-9300000000-192385d58efcfe6d927a View in MoNA Predicted GC-MS Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive Not Available View in JSpectraViewer Predicted GC-MS Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive Not Available View in JSpectraViewer Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 10V, Positive splash10-0fr2-1900000000-1952d82430e8d4d017ec View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 20V, Positive splash10-0g4i-8900000000-9b552b5028c7cac0636c View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 40V, Positive splash10-006x-9200000000-69e6a42e7b8c893be2b0 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 10V, Negative splash10-03di-3900000000-a1ac74b59a8487175409 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 20V, Negative splash10-00di-9600000000-b341efd7d7ac7e6a7652 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 40V, Negative splash10-00di-9100000000-a0987d89d6b50b5ee46a View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 10V, Positive splash10-0gi0-3900000000-72a434ff0c346ae54bf5 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 20V, Positive splash10-0fk9-9600000000-16a8930ac7a8ed9a8656 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 40V, Positive splash10-00di-9100000000-4825e58f647c6709f63e View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 10V, Negative splash10-0006-0900000000-f33be61e6a7e963f5725 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 20V, Negative splash10-0079-9200000000-d4c3022fe2d2d99ba90b View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 40V, Negative splash10-0006-9000000000-ce7c939afbade242bd22 View in MoNA 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer 1D NMR 1H NMR Spectrum Not Available View in JSpectraViewer 1D NMR 13C NMR Spectrum Not Available View in JSpectraViewer
References
References:	Not Available
Synthesis Reference:	Not Available
Material Safety Data Sheet (MSDS)	Not Available
Links
External Links:	Resource Link CHEBI ID 21285 HMDB ID HMDB0002273 Pubchem Compound ID 440854 Kegg ID C02987 ChemSpider ID 389696 Wikipedia ID Not Available BioCyc ID Not Available

Enzymes