Structural search and advanced query search is temporarily unavailable. We are working to fix this issue. Thank you for your support and patience.


Nitrous oxide (M2MDB001663)

Record Information
Version2.0
Creation Date2012-07-30 14:55:08 -0600
Update Date2015-06-03 17:21:01 -0600
Secondary Accession Numbers
  • ECMDB21255
Identification
Name:Nitrous oxide
DescriptionNitrous oxide, commonly known as laughing gas, is a chemical compound with the formula N2O. It is an oxide of nitrogen. At room temperature, it is a colorless, non-flammable gas, with a slightly sweet odor and taste. N2O is produced naturally by microorganisms in soil through various types of nitrification and denitrification processes. (Wikipedia) Nitrous oxide production by Escherichia coli seems to result from the reduction of nitrite (NO2-) by nitrate (NO3-) reductase. (PMID 6347062)
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms:
  • Diazyne 1-oxide
  • Dinitrogen monoxide
  • Dinitrogen oxide
  • Distickstoffmonoxid
  • Factitious air
  • Gaz hilarant
  • Hyponitrous acid anhydride
  • Lachgas
  • Laughing gas
  • N2O
  • Nitral
  • Nitrogen monoxide
  • Nitrogen oxide
  • Nitrogen oxide (N2O)
  • Nitrogen protoxide
  • Nitrogenium oxydulatum
  • Nitrous oxide
  • NNO
  • Oxidodinitrogen(NN)
  • Oxyde nitreux
  • Protoxyde D'azote
  • Stickstoff(1)-oxid
Chemical Formula:N2O
Weight:Average: 44.0128
Monoisotopic: 44.001062632
InChI Key:GQPLMRYTRLFLPF-UHFFFAOYSA-N
InChI:InChI=1S/N2O/c1-2-3
CAS number:10024-97-2
IUPAC Name:diazooxidane
Traditional IUPAC Name:nitrous oxide
SMILES:[O-][N+]#N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as other non-metal nitrides. These are inorganic compounds of nitrogen where nitrogen has a formal oxidation state of -3, and the heaviest atom bonded to it belongs to the class of 'other non-metals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassOther non-metal organides
Sub ClassOther non-metal nitrides
Direct ParentOther non-metal nitrides
Alternative Parents
Substituents
  • Other non-metal nitride
  • Inorganic nitride
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Liquid
Charge:0
Melting point:-90.81 °C
Experimental Properties:
PropertyValueSource
LogP:0.36PhysProp
Predicted Properties
PropertyValueSource
logP-0.021ChemAxon
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area54.46 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity27.67 m³·mol⁻¹ChemAxon
Polarizability2.54 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
Hydrogen ion + NADH + 2 Nitric oxide > Water + Nitrous oxide + NAD
2 [4Fe-4S] iron-sulfur cluster + 2 Hydrogen ion + 2 Nitric oxide >2 [3Fe-4S] damaged iron-sulfur cluster +2 Fe3+ + Water + Nitrous oxide
Nitrous oxide + Water + Cytochromes-C-Oxidized Nitric oxide + Hydrogen ion + Cytochromes-C-Reduced
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
EcoCyc Pathways:Not Available
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9000000000-eb7b02e9ea0e132b0a58View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-2eee7435817186856ef7View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001j-9000000000-d1a5381e3dd214cad7abView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000t-9000000000-3ae2e01e3d626729760bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004l-9000000000-c53ff0d270e0310b3375View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9000000000-c8b9d8f80d3f41ad7f54View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-002f-9000000000-12c3fe456373daff732eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-f78d84fc2eb278e7bb4dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-9000000000-f78d84fc2eb278e7bb4dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0002-9000000000-f78d84fc2eb278e7bb4dView in MoNA
References
References:
  • Smith, M. S. (1983). "Nitrous oxide production by Escherichia coli is correlated with nitrate reductase activity." Appl Environ Microbiol 45:1545-1547. Pubmed: 6347062
Synthesis Reference:Not Available
Material Safety Data Sheet (MSDS)Not Available
External Links:
ResourceLink
CHEBI ID17045
HMDB IDHMDB0035807
Pubchem Compound ID948
Kegg IDC00887
ChemSpider ID923
WikipediaNitrous_oxide
BioCyc IDNITROUS-OXIDE
EcoCyc IDNITROUS-OXIDE
Ligand ExpoN2O

Enzymes

Protein Details
1. Nitric oxide reductase FlRd-NAD(+) reductase
General function:
Involved in oxidation-reduction process
Specific function:
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase
Gene Name:
norW
Uniprot ID:
P37596
Molecular weight:
41403
Reactions
Reduced NO reductase rubredoxin + NAD(+) = oxidized NO reductase rubredoxin + NADH.
Protein Details
2. Anaerobic nitric oxide reductase flavorubredoxin
General function:
Involved in iron ion binding
Specific function:
Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the reductase at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase
Gene Name:
norV
Uniprot ID:
Q46877
Molecular weight:
54234

Transporters

Protein Details
1. Outer membrane protein N
General function:
Involved in transporter activity
Specific function:
Non-specific porin
Gene Name:
ompN
Uniprot ID:
P77747
Molecular weight:
41220
Protein Details
2. Outer membrane pore protein E
General function:
Involved in transporter activity
Specific function:
Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
Gene Name:
phoE
Uniprot ID:
P02932
Molecular weight:
38922
Protein Details
3. Outer membrane protein F
General function:
Involved in transporter activity
Specific function:
OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
Gene Name:
ompF
Uniprot ID:
P02931
Molecular weight:
39333
Protein Details
4. Outer membrane protein C
General function:
Involved in transporter activity
Specific function:
Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
Gene Name:
ompC
Uniprot ID:
P06996
Molecular weight:
40368